Contrast-Enhanced Computed Tomography Evaluation of Hepatic Metastases in Breast Cancer Patients Before and After Cytotoxic Chemotherapy or Targeted Therapy

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Contrast-Enhanced Computed Tomography Evaluation of Hepatic Metastases in Breast Cancer Patients Before and After Cytotoxic Chemotherapy or Targeted Therapy Hongying He, MD, PhD, Chunyan Cai, PhD, Chusilp Charnsangavej, MD, Richard L. Theriault, MD, Marjorie Green, MD, Mohammad A. Quraishi, PhD, Wei T. Yang, MD Canadian Association of Radiologists Journal Volume 66, Issue 4, Pages 356-362 (November 2015) DOI: 10.1016/j.carj.2015.03.005 Copyright © 2015 Canadian Association of Radiologists Terms and Conditions

Figure 1 (A) Box plot of sum of lesion size before and after therapy. Change in sum of lesion size is statistically significant in cytotoxic chemotherapy group (P < .0001), but not significant in targeted therapy groups (P = .07; 2-sample t test). (B) Box-plot of mean computed tomography (CT) density before and after therapy. Change in mean CT density is statistically significant in cytotoxic chemotherapy group (P = .05), but not significant in targeted therapy groups (P = .43; 2-sample t test). CX = cytotoxic chemotherapy; TT = targeted therapy. This figure is available in colour online at http://carjonline.org/. Canadian Association of Radiologists Journal 2015 66, 356-362DOI: (10.1016/j.carj.2015.03.005) Copyright © 2015 Canadian Association of Radiologists Terms and Conditions

Figure 2 (A) Pretherapy computed tomography (CT) scan in a patient who had received cytotoxic chemotherapy. The metastatic hepatic lesion (indicated by arrow) measures 4.9 cm in size and 86 Hounsfield units (HU) in CT density. (B) Post-therapy CT scan shows the same lesion measuring 2 cm in size and 20 HU in CT density (a 59% decrease in size and 77% decrease in CT density from the pretherapy scan). Canadian Association of Radiologists Journal 2015 66, 356-362DOI: (10.1016/j.carj.2015.03.005) Copyright © 2015 Canadian Association of Radiologists Terms and Conditions

Figure 3 (A) Pretherapy computed tomography (CT) scan in a patient who received targeted therapy. The metastatic hepatic lesion (indicated by arrow) measures 3.5 cm in size and 85 Hounsfield units in CT density. (B) Post-therapy CT scan shows the same lesion measuring 2.4 cm in size and 76 HU in CT density (a 20% decrease in size and 11% decrease in CT density from the pretherapy scan). Canadian Association of Radiologists Journal 2015 66, 356-362DOI: (10.1016/j.carj.2015.03.005) Copyright © 2015 Canadian Association of Radiologists Terms and Conditions