ASGE Bariatric Endoscopy Task Force systematic review and meta-analysis assessing the ASGE PIVI thresholds for adopting endoscopic bariatric therapies

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ASGE Bariatric Endoscopy Task Force systematic review and meta-analysis assessing the ASGE PIVI thresholds for adopting endoscopic bariatric therapies Barham K. Abu Dayyeh, MD, MPH, Nitin Kumar, MD, Steven A. Edmundowicz, MD, FASGE, Sreenivasa Jonnalagadda, MD, FASGE, Michael Larsen, MD, Shelby Sullivan, MD, Christopher C. Thompson, MD, MSc, FASGE, Subhas Banerjee, MD, FASGE Gastrointestinal Endoscopy Volume 82, Issue 3, Pages 425-438.e5 (September 2015) DOI: 10.1016/j.gie.2015.03.1964 Copyright © 2015 Terms and Conditions

Figure 1 Flow diagram depicting search findings and study selection for inclusion in the intragastric balloon meta-analyses. CCRT, Cochrane Central Register of Controlled Trials; CDSR, Cochrane Database of Systematic Reviews; %EWL, percentage of excess weight loss; %TBWL, percentage of total body weight loss. Gastrointestinal Endoscopy 2015 82, 425-438.e5DOI: (10.1016/j.gie.2015.03.1964) Copyright © 2015 Terms and Conditions

Figure 2 Flow diagram depicting search findings and study selection for inclusion in the EndoBarrier meta-analyses. CCRT, Cochrane Central Register of Controlled Trials; CDSR, Cochrane Database of Systematic Reviews; %EWL, percentage of excess weight loss; HgA1c, glycosylated hemoglobin; RCTs, randomized, controlled trials. Gastrointestinal Endoscopy 2015 82, 425-438.e5DOI: (10.1016/j.gie.2015.03.1964) Copyright © 2015 Terms and Conditions

Figure 3 Forest plot of studies evaluating the percentage of excess weight loss (%EWL) at 12 months after intragastric balloon (IGB) implantation. Gastrointestinal Endoscopy 2015 82, 425-438.e5DOI: (10.1016/j.gie.2015.03.1964) Copyright © 2015 Terms and Conditions

Figure 4 Forest plot of studies evaluating the mean difference in the percentage of excess weight loss (%EWL) compared with sham or control groups after intragastric balloon (IGB) implantation. RCTs, randomized, controlled trials. Gastrointestinal Endoscopy 2015 82, 425-438.e5DOI: (10.1016/j.gie.2015.03.1964) Copyright © 2015 Terms and Conditions

Figure 5 Forest plot of studies evaluating the percentage of excess weight loss (%EWL) at 12 months after EndoBarrier implantation. Gastrointestinal Endoscopy 2015 82, 425-438.e5DOI: (10.1016/j.gie.2015.03.1964) Copyright © 2015 Terms and Conditions

Figure 6 Forest plot of studies evaluating the mean difference in the percentage of excess weight loss (%EWL) compared with the sham or control groups after EndoBarrier implantation. RCTs, randomized, controlled trials. Gastrointestinal Endoscopy 2015 82, 425-438.e5DOI: (10.1016/j.gie.2015.03.1964) Copyright © 2015 Terms and Conditions

Figure 7 Forest plot depicting changes in glycosylated hemoglobin (HgA1c) after 12, 24, and 52 weeks of EndoBarrier implantation. Gastrointestinal Endoscopy 2015 82, 425-438.e5DOI: (10.1016/j.gie.2015.03.1964) Copyright © 2015 Terms and Conditions

Figure 8 Forest plot of studies reporting mean difference in glycosylated hemoglobin (HgA1c) between EndoBarrier and sham or control groups in randomized, controlled trials (RCTs). CI, confidence interval. Gastrointestinal Endoscopy 2015 82, 425-438.e5DOI: (10.1016/j.gie.2015.03.1964) Copyright © 2015 Terms and Conditions

Figure 9 Forest plot of studies reporting the percentage of total body weight loss (%TBWL) after Orbera intragastric balloon implantation. Gastrointestinal Endoscopy 2015 82, 425-438.e5DOI: (10.1016/j.gie.2015.03.1964) Copyright © 2015 Terms and Conditions

Figure 10 Meta-regression linear plot depicting the best-fit regression line of the association between baseline body mass indexes (BMIs) and percentage of excess weight loss (%EWL) at 6 months after Orbera intragastric balloon (IGB) implantation. The sample size of individual studies is proportional to the diameter of the circle by which it is represented on the graph. Gastrointestinal Endoscopy 2015 82, 425-438.e5DOI: (10.1016/j.gie.2015.03.1964) Copyright © 2015 Terms and Conditions

Figure 11 Pooled rates of adverse events observed with the Orbera intragastric balloon (IGB). SBO, small bowel obstruction. Gastrointestinal Endoscopy 2015 82, 425-438.e5DOI: (10.1016/j.gie.2015.03.1964) Copyright © 2015 Terms and Conditions

Figure 12 Pooled rates of adverse events observed with the EndoBarrier. Gastrointestinal Endoscopy 2015 82, 425-438.e5DOI: (10.1016/j.gie.2015.03.1964) Copyright © 2015 Terms and Conditions