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Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2015.132 Figure 1 Allopurinol hypersensitivity includes MPE, AHS and allopurinol-induced SCAR Figure 1 | Allopurinol hypersensitivity includes MPE, AHS and allopurinol-induced SCAR. AHS and allopurinol-induced SCAR overlap considerably. Allopurinol-induced SCAR includes SJS/TEN and DRESS. The size of the circles in this figure in no way relate to the frequency of these adverse reactions. Abbreviations: AHS, allopurinol hypersensitivity syndrome; DRESS, drug reaction with eosinophilia and systemic symptoms; MPE, maculopapular eruption; SCAR, severe cutaneous adverse reactions; SJS, Stevens–Johnson syndrome; TEN, toxic epidermal necrolysis. Stamp, L. K. et al. (2015) Allopurinol hypersensitivity: investigating the cause and minimizing the risk Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2015.132