Capsaicin 8% patch for treprostinil subcutaneous infusion site pain in pulmonary hypertension patients V. Libri, J.S.R. Gibbs, D.J. Pinato, T. Iddamalgoda,

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Presentation transcript:

Capsaicin 8% patch for treprostinil subcutaneous infusion site pain in pulmonary hypertension patients V. Libri, J.S.R. Gibbs, D.J. Pinato, T. Iddamalgoda, R.H. Khengar, W. Gin-Sing, L. Huson, P. Anand British Journal of Anaesthesia Volume 112, Issue 2, Pages 337-347 (February 2014) DOI: 10.1093/bja/aet308 Copyright © 2014 The Author(s) Terms and Conditions

Fig 1 Study flow diagram. PGIC, patient global impression of change. British Journal of Anaesthesia 2014 112, 337-347DOI: (10.1093/bja/aet308) Copyright © 2014 The Author(s) Terms and Conditions

Fig 2 Patient disposition and data analysis. British Journal of Anaesthesia 2014 112, 337-347DOI: (10.1093/bja/aet308) Copyright © 2014 The Author(s) Terms and Conditions

Fig 3 (a) Individual mean changes in NPRS pain score after capsaicin 8% patch application relative to baseline in eight PAH patients completing both treatment periods; (b) and (c) examples of capsaicin 8% patch and control effects in two different patients. British Journal of Anaesthesia 2014 112, 337-347DOI: (10.1093/bja/aet308) Copyright © 2014 The Author(s) Terms and Conditions

Fig 4 (a) Heat pain threshold change in patients pre- and post-capsaicin 8% and control patch applications. Base mean flux change in patients pre- and post-capsaicin 8% patch and control patch applications in (b) target, (c) adjacent, and (d) contralateral areas. Base mean flux change values for patient 004 are depicted with open circles. British Journal of Anaesthesia 2014 112, 337-347DOI: (10.1093/bja/aet308) Copyright © 2014 The Author(s) Terms and Conditions

Fig 5 Representative photograph (left) and laser Doppler flux (right) images of patients post-control (a) and post-capsaicin 8% patch (b) application. British Journal of Anaesthesia 2014 112, 337-347DOI: (10.1093/bja/aet308) Copyright © 2014 The Author(s) Terms and Conditions