Patrick H. Archie, MD, Mary Beth Beasley, MD, Helen J. Ross, MD

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Presentation transcript:

Biphasic Pulmonary Blastoma with Germ Cell Differentiation in a 36-Year-Old Man Patrick H. Archie, MD, Mary Beth Beasley, MD, Helen J. Ross, MD Journal of Thoracic Oncology Volume 3, Issue 10, Pages 1185-1187 (October 2008) DOI: 10.1097/JTO.0b013e31818721fa Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Computed tomography of the chest shows a 13 cm anterior mediastinal mass. Journal of Thoracic Oncology 2008 3, 1185-1187DOI: (10.1097/JTO.0b013e31818721fa) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Computed tomography of the chest at the time of surgical biopsy shows rapid progression in 19 days. Mediastinal tumor now measures 18.5 cm and compresses the left pulmonary artery and the left mainstem bronchus. Journal of Thoracic Oncology 2008 3, 1185-1187DOI: (10.1097/JTO.0b013e31818721fa) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 Approximately 70% of the biopsy specimen contained classic biphasic pulmonary blastoma (CBPB) with malignant glands growing in tubules resembling fetal bronchioles (hematoxylin and eosin, 100×). The remainder of the specimen (not shown) contained teratoma (immature mesenchymal stroma with abortive hair follicle development), seminoma (positive for placental alkaline phosphatase), and embryonal carcinoma (high grade undifferentiated cells positive for CD30 and cytokeratin). Journal of Thoracic Oncology 2008 3, 1185-1187DOI: (10.1097/JTO.0b013e31818721fa) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions