New tubular bioabsorbable knitted airway stent: Biocompatibility and mechanical strength Yukihito Saito, MDa, Kenichirou Minami, MDa, Masashi Kobayashi,

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New tubular bioabsorbable knitted airway stent: Biocompatibility and mechanical strength Yukihito Saito, MDa, Kenichirou Minami, MDa, Masashi Kobayashi, MDa, Yoshihisa Nakao, MDa, Hideyasu Omiya, MDa, Hiroji Imamura, MDa, Noriko Sakaida, MDb, Akiharu Okamura, MDc The Journal of Thoracic and Cardiovascular Surgery Volume 123, Issue 1, Pages 161-167 (January 2002) DOI: 10.1067/mtc.2002.118503 Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 Silicone stent (left) and tubular knitted PLLA stent (right). The Journal of Thoracic and Cardiovascular Surgery 2002 123, 161-167DOI: (10.1067/mtc.2002.118503) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 Schema of measurement of diameter of stents with a noncontact profile projector. The Journal of Thoracic and Cardiovascular Surgery 2002 123, 161-167DOI: (10.1067/mtc.2002.118503) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 Bronchoscopic findings in group A (silicone): A, Immediately after stent implantation; B, severe airway stenosis 8 weeks after implantation; and C, after removal of silicone stent, obstructive material was visible inside the stent. The Journal of Thoracic and Cardiovascular Surgery 2002 123, 161-167DOI: (10.1067/mtc.2002.118503) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 4 Bronchoscopic findings in group B (PLLA). A, Immediately after stent implantation; B, 8 weeks after implantation, airway was fully open; C, 20 weeks after implantation, a part of the PLLA stent was not visible because it was covered with tracheal epithelium; and D, 40 weeks after implantation, the PLLA stent was absorbed, and nonabsorbable suture in the bronchial wall was observed. The Journal of Thoracic and Cardiovascular Surgery 2002 123, 161-167DOI: (10.1067/mtc.2002.118503) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 5 Histologic findings in both groups. A, Epithelial erosion was observed under the stent 8 weeks after implantation (group A). B, Epithelium was preserved, and numerous capillary blood vessels in the submucosa were observed 8 weeks after implantation (group B). The Journal of Thoracic and Cardiovascular Surgery 2002 123, 161-167DOI: (10.1067/mtc.2002.118503) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 6 Scanning electron microscopic findings in both groups. A and B Marked regression of ciliated cells under the stent 8 weeks after implantation (group A). (A, original magnification 500 ×; B, original magnification 2000×.) C and D, Ciliated cells were preserved between the mesh holes of the stent 8 weeks after implantation (group B). (C, original magnification 100×; D, original magnification 1000×.) *PLLA wire. The Journal of Thoracic and Cardiovascular Surgery 2002 123, 161-167DOI: (10.1067/mtc.2002.118503) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 7 Comparison of deformation rate in 2 types of airway stents. Between 4 and 6 mm, the deformation rate of silicone stents was significantly lower than that of PLLA stents. At diameters of 10 and 13 mm, the deformation rate of PLLA stents was significantly lower than that of silicone stents. The Journal of Thoracic and Cardiovascular Surgery 2002 123, 161-167DOI: (10.1067/mtc.2002.118503) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions