Sonidegib (LDE-225), a Sonic Hedgehog Pathway Inhibitor, for the Treatment of Steroid- Refractory Chronic Graft-Versus-Host Disease Zachariah DeFilipp,

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Presentation transcript:

Sonidegib (LDE-225), a Sonic Hedgehog Pathway Inhibitor, for the Treatment of Steroid- Refractory Chronic Graft-Versus-Host Disease Zachariah DeFilipp, Rosalynn M. Nazarian, Shuli Li, Jami Brown, Karen K. Ballen, Areej R. El-Jawahri, Steven L. McAfee, Joseph H. Antin, Corey S. Cutler, Jacalyn Rosenblatt, Yi-Bin Chen Biology of Blood and Marrow Transplantation Volume 23, Issue 3, Pages S364-S365 (March 2017) DOI: 10.1016/j.bbmt.2016.12.312 Copyright © 2016 Terms and Conditions

Figure 1 H&E stained sections from pre- (Panel A) and post- (Panel B) Smo inhibition show epidermal atrophy and dermal sclerosis appearing somewhat alleviated following Smo inhibition. A reduction in the intensity of Beta-catenin expression from moderate (Panel C) to faint-none post-Smo inhibition (Panel D) within cytoplasm of dermal fibroblasts (arrows). Biology of Blood and Marrow Transplantation 2017 23, S364-S365DOI: (10.1016/j.bbmt.2016.12.312) Copyright © 2016 Terms and Conditions