Argentina Arg-ADNI Ezequiel Surace, PhD

Arg-ADNI Status 2012 Baseline Follow-up Follow-up Healthy Controls 15 Total Nº NPS Ass MRI CSF Aβ-tau PET FDG PET PiB Follow-up 1 year Follow-up 30 month Follow-up 60 month Healthy Controls 15 11 13 12 8 Early MCI 7 10 6 Late MCI 16 14 4 Dementia AD 9 2 TOTAL 56 40 (71%) 53 (95%) 50 (89%) 43

Reason for delay of the visit Too far from the center: 3 Arg-ADNI Drop-out rates 2012 2017 2018 Patients Followed (60 months) Nº= 14 (so far…) Patients Followed (Baseline) Nº= 56 Patients Followed (1st year) Nº= 50 Patients Followed (30 months) Nº= 43 Drop-out rate 10.7% Nº= 6 Drop-out rate 14% Nº= 7 Reason for delay of the visit Drop-out: 3 Passed away: 4 Too far from the center: 3 Hospitalized: 4

60-month visit (ongoing) (Only for PiB- at baseline) Arg-ADNI 60-month visit (ongoing) 60-month visit Baseline Follow-up 60 month NPS Ass Alz Costs Survey MRI CSF PET PiB (Only for PiB- at baseline) PET-tau AV-1451 Healthy Controls 15 8 x Early MCI 12 Late MCI 16 4 Dementia AD 13 2 TOTAL 56 14

has funded this study completely Arg-ADNI Limitations Small cohort generates difficulties in data analysis Baseline Follow-up Initially, our intention was to apply for grants to increase cohort number, but: Available grants contemplate incorporation of preventive interventions. Also, these grants are not sufficient for “omics” analyses From the participant’s standpoint: they manifest less enthusiasm to participate, especially of they are already symptomatic We have not been able to convince other Latin American centers to participate in order to share efforts has funded this study completely

Arg-ADNI Future directions We will complete the 60-month visit (estimated 1 more year) Baseline Follow-up Data analysis will take a further year For now, we do not anticipate to extend the protocol further Based on the limitations, it would be more feasible to apply to preclinical intervention-based grants Arg-ADNI group will participate in FINGER meeting, AA LATAM Face to Face and Alzheimer Prevention Initiative during this meeting

Arg-ADNI What we have learned ADNI served as a model of how other similar initiatives should be implemented and standarized in our institution PiB-PET, Tau-PET, Spanish adaptation of neuropsychological tests, CSF biomarkers (QC program) Administration of data from multiple sources into integrated databases Consolidation of a multi-disciplinary group

IASDA ARGENTINE INITIATIVE FOR THE STUDY OF DOWN SYNDROME AND ALZHEIMER’S Established December 2017 3-year longitudinal study CSF biomarkers Yearly clinical / neuropsychological evaluation Confirmatory cytogenetic study DNA / Plasma Structural MRI PiB-PET /FDG-PET

IASDA ARGENTINE INITIATIVE FOR THE STUDY OF DOWN SYNDROME AND ALZHEIMER’S Established December 2017 Completed Baseline 2018-2019 Remaining 10 Recruit 5 more participants Neuropsychological assessment MRI Participants recruited: 15 Women: 9 Median age : 41 (21-58)