Volume 95, Issue 1, Pages (January 2019)

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Volume 95, Issue 1, Pages 178-187 (January 2019) Progression of diabetic kidney disease and trajectory of kidney function decline in Chinese patients with Type 2 diabetes Guozhi Jiang, Andrea On Yan Luk, Claudia Ha Ting Tam, Fangying Xie, Bendix Carstensen, Eric Siu Him Lau, Cadmon King Poo Lim, Heung Man Lee, Alex Chi Wai Ng, Maggie Chor Yin Ng, Risa Ozaki, Alice Pik Shan Kong, Chun Chung Chow, Xilin Yang, Hui-yao Lan, Stephen Kwok Wing Tsui, Xiaodan Fan, Cheuk Chun Szeto, Wing Yee So, Juliana Chung Ngor Chan, Ronald Ching Wan Ma Ronald C.W. Ma, Juliana C.N. Chan, Yu Huang, Hui-yao Lan, Si Lok, Brian Tomlinson, Stephen K.W. Tsui, Weichuan Yu, Kevin Y.L. Yip, Ting Fung Chan, Xiaodan Fan, Wing Yee So, Cheuk Chun Szeto, Nelson L.S. Tang, Andrea O. Luk, Xiaoyu Tian, Guozhi Jiang, Claudia H.T. Tam, Heung Man Lee, Cadmon K.P. Lim, Katie K.H. Chan, Fangying Xie, Alex C.W. Ng, Grace P.Y. Cheung, Ming-wai Yeung, Shi Mai, Fei Xie, Sen Zhang, Pu Yu, Meng Weng Guozhi Jiang, Andrea On Yan Luk, Claudia Ha Ting Tam, Fangying Xie, Bendix Carstensen, Eric Siu Him Lau, Cadmon King Poo Lim, Heung Man Lee, Alex Chi Wai Ng, Maggie Chor Yin Ng, Risa Ozaki, Alice Pik Shan Kong, Chun Chung Chow, Xilin Yang, Hui-yao Lan, Stephen Kwok Wing Tsui, Xiaodan Fan, Cheuk Chun Szeto, Wing Yee So, Juliana Chung Ngor Chan, Ronald Ching Wan Ma Ronald C.W. Ma, Juliana C.N. Chan, Yu Huang, Hui-yao Lan, Si Lok, Brian Tomlinson, Stephen K.W. Tsui, Weichuan Yu, Kevin Y.L. Yip, Ting Fung Chan, Xiaodan Fan, Wing Yee So, Cheuk Chun Szeto, Nelson L.S. Tang, Andrea O. Luk, Xiaoyu Tian, Guozhi Jiang, Claudia H.T. Tam, Heung Man Lee, Cadmon K.P. Lim, Katie K.H. Chan, Fangying Xie, Alex C.W. Ng, Grace P.Y. Cheung, Ming-wai Yeung, Shi Mai, Fei Xie, Sen Zhang, Pu Yu, Meng Weng Kidney International Volume 95, Issue 1, Pages 178-187 (January 2019) DOI: 10.1016/j.kint.2018.08.026 Copyright © 2018 International Society of Nephrology Terms and Conditions

Kidney International 2019 95, 178-187DOI: (10.1016/j.kint.2018.08.026) Copyright © 2018 International Society of Nephrology Terms and Conditions

Figure 1 Flowchart of sample selection from the Hong Kong Diabetes Register. eGFR, estimated glomerular filtration rate; ESRD, end-stage renal disease; T1, type 1 diabetes. Kidney International 2019 95, 178-187DOI: (10.1016/j.kint.2018.08.026) Copyright © 2018 International Society of Nephrology Terms and Conditions

Figure 2 Trajectories of estimated glomerular filtration rate (eGFR) and 95% confidence intervals derived from the joint latent class model for a hypothetical 55-year-old man with 5 years of disease duration and no proteinuria at baseline (Bayesian Information Criterion = –150169.4). The horizontal dashed line indicates that the eGFR was equal to 15 ml/min per 1.73 m2. The data in parentheses represent the number (percentage) of persons in each class. Class 1: slow eGFR decline; class 2: curvilinear eGFR decline; class 3: progressive eGFR decline; class 4: accelerated eGFR decline. Kidney International 2019 95, 178-187DOI: (10.1016/j.kint.2018.08.026) Copyright © 2018 International Society of Nephrology Terms and Conditions