Aspirin resistance among long-term aspirin users after carotid endarterectomy and controls: Flow cytometric measurement of aspirin-induced platelet inhibition

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Aspirin resistance among long-term aspirin users after carotid endarterectomy and controls: Flow cytometric measurement of aspirin-induced platelet inhibition Afshin Assadian, MD, Jaqueline Lax, MS, Ursula Meixner-Loicht, MD, Georg W. Hagmüller, MD, Peter Michael Bayer, MD, Wolfgang Hübl, MD Journal of Vascular Surgery Volume 45, Issue 6, Pages 1142-1147 (June 2007) DOI: 10.1016/j.jvs.2007.01.064 Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 1 Activation of platelets by arachidonic acid (ARA): all 86 patients receiving long-term low-dose aspirin medication (ASP) showed inhibition of ARA-induced platelet activation (ie, <15% CD62p-positive platelets), whereas two of 29 patient controls without reported history of aspirin intake (PCON) demonstrated cyclooxygenase inhibition. The threshold of 15% is marked by the dashed line. Journal of Vascular Surgery 2007 45, 1142-1147DOI: (10.1016/j.jvs.2007.01.064) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 2 PFA-100 collagen-epinephrine closure time (CEPI-CT): 14 of 86 patients showed a normal CEPI-CT despite long-term low-dose aspirin medication (ASP). Four of 29 patient controls without an apparent history of aspirin intake (PCON) had an elevated CEPI-CT. The upper reference limit (165 seconds) is marked by the dashed line. Journal of Vascular Surgery 2007 45, 1142-1147DOI: (10.1016/j.jvs.2007.01.064) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions