Comparison of the effects of thoracic epidural analgesia and i. v

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Presentation transcript:

Comparison of the effects of thoracic epidural analgesia and i. v Comparison of the effects of thoracic epidural analgesia and i.v. infusion with lidocaine on cytokine response, postoperative pain and bowel function in patients undergoing colonic surgery C.P. Kuo, S.W. Jao, K.M. Chen, C.S. Wong, C.C. Yeh, M.J. Sheen, C.T. Wu British Journal of Anaesthesia Volume 97, Issue 5, Pages 640-646 (November 2006) DOI: 10.1093/bja/ael217 Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 1 VAS pain scores at rest (a) and during coughing (b). Resting VAS pain scores were significantly lower at 2 and 4 h after surgery in the IV (i.v. lidocaine) and TEA (thoracic epidural analgesia with lidocaine) groups compared with the control group. Coughing VAS pain scores were significantly lower at 12 h and at day 2 (D2) after surgery in the IV and TEA groups compared with the control group. Resting and coughing VAS pain scores were significantly higher at 4 and 12 h after surgery in the IV group compared with the TEA group. Values are mean (sd). ♦P<0.001 compared with IV and control groups, °P<0.001 compared with the control group, •P<0.001 compared with the control group, ⋄P<0.001 compared with the IV group. GP, Group. British Journal of Anaesthesia 2006 97, 640-646DOI: (10.1093/bja/ael217) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 2 Total patient-controlled epidural analgesia (PCEA) delivery times more than 3 days (D) after surgery. Total delivery times in TEA (thoracic epidural analgesia with lidocaine) or IV (i.v. lidocaine) group were less than those in the control group. °P<0.01 compared with the control group, •P<0.01 compared with the control group, ⋄P<0.01 compared with IV group. GP, Group. British Journal of Anaesthesia 2006 97, 640-646DOI: (10.1093/bja/ael217) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 3 Mean plasma concentrations of interleukin (IL)-6 (a), IL-8 (b) and IL-1 receptor antagonist (IL-1RA) (c) concentrations, mean (sd). ♦P<0.01 in TEA (thoracic epidural analgesia with lidocaine) group compared with IV (i.v. lidocaine) and control groups, °P<0.01 in IV group compared with control group; ⋄P<0.01 in TEA compared with IV group. GP, Group. British Journal of Anaesthesia 2006 97, 640-646DOI: (10.1093/bja/ael217) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions