MicroRNAs and Parallel Stem Cell Lives

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MicroRNAs and Parallel Stem Cell Lives Peter B. Dirks Cell Volume 138, Issue 3, Pages 423-424 (August 2009) DOI: 10.1016/j.cell.2009.07.025 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 MicroRNAs Target BMI1 to Block Self-Renewal MicroRNA-200c (miR-200c) shows decreased expression in breast cancer stem cells compared to cancer cells in the bulk tumor. Normal mammary epithelial stem cells show lower expression of miR-200c than differentiated cells. It is possible that miR-200c blocks stem cell self-renewal by targeting the 3′UTR of the self-renewal gene BMI1, resulting in loss of BMI1 protein,and attenuation of the ability of cancer stem cells to self-renew and form tumors. Cell 2009 138, 423-424DOI: (10.1016/j.cell.2009.07.025) Copyright © 2009 Elsevier Inc. Terms and Conditions