Successful treatment of acute, ongoing rat lung allograft rejection with the novel immunosuppressant SDZ-RAD Bernard Hausen, MD, PhD, Katrin Boeke, BS,

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Successful treatment of acute, ongoing rat lung allograft rejection with the novel immunosuppressant SDZ-RAD Bernard Hausen, MD, PhD, Katrin Boeke, BS, Gerald J Berry, MD, Uwe Christians, MD, PhD, Walter Schüler, PhD, Randall E Morris, MD The Annals of Thoracic Surgery Volume 69, Issue 3, Pages 904-909 (March 2000) DOI: 10.1016/S0003-4975(99)01504-0

Fig 1 Comparison of the histology scores of acute lung rejection in individual rats. (A0 = no rejection, A1 = minimal rejection, A2 = mild rejection, A3 = moderate rejection, A4 = severe rejection.) One-way analysis of variance on ranks: Control versus cyclosporine + SDZ-RAD (group IV): p < 0.001; control versus graft rescue group (group V): p < 0.002; microemulsion CsA monotherapy (group III) vs cyclosporine + SDZ-RAD (group IV) p = not significant; microemulsion CsA monotherapy (group III) vs graft rescue therapy (group V) p < 0.05. The Annals of Thoracic Surgery 2000 69, 904-909DOI: (10.1016/S0003-4975(99)01504-0)

Fig 2 Mean trough blood concentrations of cyclosporine (A) and SDZ-RAD (B) in lung transplant rats. Data are presented as mean ± standard error of the mean. Statistical significance was evaluated by one-way analysis of variance with posthoc tests. The Annals of Thoracic Surgery 2000 69, 904-909DOI: (10.1016/S0003-4975(99)01504-0)

Fig 3 Mean weight as a percentage of initial weight at the day of surgery. Comparison using repeated measures analysis of variance: control versus cyclosporine + SDZ-RAD (group IV) p < 0.0001, control versus graft rescue group (group V) p < 0.04. The Annals of Thoracic Surgery 2000 69, 904-909DOI: (10.1016/S0003-4975(99)01504-0)