Chimeric Antigen Receptor (CAR) T Cell Immunotherapy for Poor Risk Sarcomas Xin Huang, MD, Joseph Greene, BA, James Pao, BA, Erin Mulvey, BA, Sophia X.

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Chimeric Antigen Receptor (CAR) T Cell Immunotherapy for Poor Risk Sarcomas Xin Huang, MD, Joseph Greene, BA, James Pao, BA, Erin Mulvey, BA, Sophia X. Zhou, Deepali Sachdev, PhD, Douglas Yee, MD, Christoph Rader, PhD, Catherine M. Albert, MD, Haein Park, PhD, Yaya Chu, PhD, Carl Hamby, PhD, David Loeb, MD, PhD, Mitchell S. Cairo, MD, Xianzheng Zhou, PhD Biology of Blood and Marrow Transplantation Volume 20, Issue 2, Pages S184-S185 (February 2014) DOI: 10.1016/j.bbmt.2013.12.302 Copyright © 2014 Terms and Conditions

Figure 1 In vitro and in vivo anti-sarcoma activity of IGF-1R and ROR1 CAR T cells. (A) Cytotoxicity assays. (B) Anti-sarcoma activity in a systemic model. SaOS2-fflucN cells (7.5×105) were i.v. injected into NSG mice for 5 days, treated with mock, IGF-1R CAR and ROR1 CAR T cells (1×107) on day 6 and 9, and imaged for tumor control on day 11, 17, 24, 31 and 38. (C) Survival benefit of CAR T cells in a local sarcoma model. SaOS2-fflucN (3×105) cells were i.p. injected in NOD/SCID mice, untreated or treated with mock, IGF-1R (IGZ) CAR and ROR1 CAR T cells on day 3, 5 and 7, and monitored for survival. Biology of Blood and Marrow Transplantation 2014 20, S184-S185DOI: (10.1016/j.bbmt.2013.12.302) Copyright © 2014 Terms and Conditions