during the alloimmune response

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Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc. Chapter 67 Review of the Immune System.

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during the alloimmune response Figure 1 The immunomodulatory effects of mesenchymal stromal cells (MSCs) during the alloimmune response Figure 1 | The immunomodulatory effects of mesenchymal stromal cells (MSCs) during the alloimmune response. In response to recognition of donor alloantigens via the direct or indirect pathways, CD4+ effector T cells differentiate into type 1 T helper (TH1) cells, which produce interferon-γ (IFNγ) and IL-2. IFNγ promotes graft infiltration of T cells, which activate macrophages resulting in a destructive delayed type hypersensitivity reaction. Antibody-mediated graft damage occurs as a result of complement activation or through the recruitment of cytotoxic CD8+ T cells. MSCs interfere with the effector functions of dendritic cells, naive and memory CD4+ and CD8+ T cells, macrophages and B cells through various mechanisms, and might also promote the generation of regulatory T (TREG) cells, B cells and M2 macrophages. APC, antigen-presenting cell. Remuzzi, G. et al. (2016) Mesenchymal stromal cells in renal transplantation: opportunities and challenges Nat. Rev. Nephrol. doi:10.1038/nrneph.2016.7