O. Picker, A. W. Schindler, L. A. Schwarte, B. Preckel, W. Schlack, T

Slides:

Advertisements

Similar presentations

C. Vollmer, S. Weiß, C. Beck, I. Bauer, O. Picker

Advertisements

Presynaptic inhibition of the release of multiple major central nervous system neurotransmitter types by the inhaled anaesthetic isoflurane R.I. Westphalen,

The influence of xenon on regulation of the autonomic nervous system in patients at high risk of perioperative cardiac complications† Hanss R , Bein.

Model-based administration of inhalation anaesthesia. 3

Estimation of changes in cardiac output from the arterial blood pressure waveform in the upper limb†,†† N.W.F. Linton, R.A.F. Linton British Journal.

Comparison of bioreactance and echocardiographic non-invasive cardiac output monitoring and myocardial function assessment in primagravida women A. Doherty,

Comparison of alfentanil, fentanyl and sufentanil for total intravenous anaesthesia with propofol in patients undergoing coronary artery bypass surgery†

Comparison of coagulation and blood loss during anaesthesia with inhaled isoflurane or intravenous propofol N.L. Law, K.F.J. Ng, M.G. Irwin, J.S.F. Man

A different use of visual analytic techniques in anaesthetics

Comparison of pattern of breathing with other measures of induction of anaesthesia, using propofol, methohexital, and sevoflurane† T.L. Strickland, G.B.

Effects of intracoronary calcium chloride on regional oxygen balance and mechanical function in normal and stunned myocardium in dogs K.Y. Yoo, J.U.

D. Ebel, P. Lipfert, J. FraÕßdorf, B. Preckel, J. MuÕllenheim, V

Prediction of volatile anaesthetic solubility in blood and priming fluids for extracorporeal circulation R.-G. Yu, J.-X. Zhou, J Liu British Journal.

B.M.Q. Weaver, G.E. Staddon, W.W. Mapleson

O. Thom, D. M. Taylor, R. E. Wolfe, J. Cade, P. Myles, H. Krum, R

J. Hofland, I. GuÕltuna, R. Tenbrinck British Journal of Anaesthesia

Development of atelectasis and arterial to end-tidal Pco2-difference in a porcine model of pneumoperitoneum C.M. Strang, T. Hachenberg, F. Fredén, G.

Double-blind, placebo-controlled analgesic study of ibuprofen or rofecoxib in combination with paracetamol for tonsillectomy in children A.E. Pickering,

Continuous intra-jugular venous blood-gas monitoring with the Paratrend 7 during hypothermic cardiopulmonary bypass† H. Endoh, T. Honda, S. Oohashi,

Uptake of isoflurane during prolonged clinical anaesthesia

A. Vincelot, N. Nathan, D. Collet, Y. Mehaddi, P. Grandchamp, A. Julia

Correlating in vivo anaesthetic effects with ex vivo receptor density data supports a GABAergic mechanism of action for propofol, but not for isoflurane †‡

Spasmolytic effects of prostaglandin E1 on serotonin-induced bronchoconstriction and pulmonary hypertension in dogs Y. Hashimoto, K. Hirota, H. Yoshioka,

Psychology of pain British Journal of Anaesthesia

Anoxic depolarization of rat hippocampal slices is prevented by thiopental but not by propofol or isoflurane R. Sasaki, K. Hirota, S.H. Roth, M. Yamazaki

Bispectral analysis of the electroencephalogram does not predict responsiveness to verbal command in patients emerging from xenon anaesthesia† T. Goto,

Which is most pungent: isoflurane, sevoflurane or desflurane?

Effects of thoracic epidural anaesthesia on microvascular gastric mucosal oxygenation in physiological and compromised circulatory conditions in dogs†

Pressure recording analytical method (PRAM) for measurement of cardiac output during various haemodynamic states S. Scolletta, S.M. Romano, B. Biagioli,

Y. -F. Chai, J. Yang, J. Liu, H. -B. Song, J. -W. Yang, S. -L. Liu, W

Postoperative changes in visual evoked potentials and cognitive function tests following sevoflurane anaesthesia G. Iohom, I. Collins, D. Murphy, I.

Bispectral index is related to the spread of spinal sensory block in patients with combined spinal and general anaesthesia R Iida, K Iwasaki, J Kato,

The output of two sevoflurane vaporizers in the presence of helium

Accuracy of feedback-controlled oxygen delivery into a closed anaesthesia circuit for measurement of oxygen consumption† A.W. Schindler, T.W.L. Scheeren,

Systemic oxygen extraction during exercise at high altitude

Trendelenburg position with hip flexion as a rescue strategy to increase spinal anaesthetic level after spinal block† J.-T. Kim, J.-K. Shim, S.-H. Kim,

S.G. Sakka, K. Reinhart, A. Meier-Hellmann

E. Saraceni, S. Rossi, P. Persona, M. Dan, S. Rizzi, M. Meroni, C. Ori

Effects of haemoglobin-based oxygen carrier Hemoglobin glutamer-200 (bovine) on intestinal perfusion and oxygenation in a canine hypovolaemia model B.

Cerebral oxygen saturation and cardiac output during anaesthesia in sitting position for neurosurgical procedures: a prospective observational study

H Viitanen, P Annila British Journal of Anaesthesia

Tissue oxygen tension (PTO2) in anaesthesia and perioperative medicine

Optimizing cerebral oxygenation in anaesthetized patients with carotid artery stenosis: the influence of inspired oxygen fraction P. Picton, S.K. Ramachandran,

Review of management of purpura fulminans and two case reports

J.J. Vos, T.W.L. Scheeren, S.A. Loer, A. Hoeft, J.K.G. Wietasch

Individual patient data analysis of tidal volumes used in three large randomized control trials involving patients with acute respiratory distress syndrome

Effect of changes in arterial-mixed venous oxygen content difference (C(a– v _ )O2) on indices of pulmonary oxygen transfer in a model ARDS lung†,††

Model-based administration of inhalation anaesthesia. 4

G.B. Drummond, B. Lafferty British Journal of Anaesthesia

Teamwork, communication, and anaesthetic assistance in Scotland

Stress response during weaning after cardiac surgery

Xenon produces minimal haemodynamic effects in rabbits with chronically compromised left ventricular function B. Preckel, W. Schlack, T. Heibel, H. Rütten

Performance of cardiac output measurement derived from arterial pressure waveform analysis in patients requiring high-dose vasopressor therapy S. Metzelder,

Diffusion of nitrous oxide into the pleural cavity†

Assessment of pulse transit time to indicate cardiovascular changes during obstetric spinal anaesthesia† G Sharwood-Smith, J Bruce, G Drummond British.

Reduction of vasopressor requirement by hydrocortisone administration in a patient with cerebral vasospasm J.A. Alhashemi British Journal of Anaesthesia

Comparison of relaxant effects of propofol on methacholine-induced bronchoconstriction in dogs with and without vagotomy S Kabara, K Hirota, E Hashiba,

Elevated serum concentrations of erythropoietin after xenon anaesthesia in cardiac surgery: secondary analysis of a randomized controlled trial C. Stoppe,

A practical method of measuring oxygen consumption in children with complex mixing circulations by the use of thermodilution cardiac output studies Daryl.

Comparison of the role of endothelin, vasopressin and angiotensin in arterial pressure regulation during sevoflurane anaesthesia in dogs O Picker, L.A.

T. Suzuki, K. Iwasaki, N. Fukano, S. Hariya, S. Saeki, S. Ogawa

D.A. Rowney, R. Fairgrieve, B. Bissonnette

S.J. Olday, R. Walpole, J.Y.Y. Wang British Journal of Anaesthesia

Voltage changes in the lithium dilution cardiac output sensor after exposure to blood from horses given xylazine T.D. Ambrisko, Y. Moens British Journal.

D. Obal, B. Preckel, H. Scharbatke, J. Müllenheim, F. Höterkes, V

Study to determine the repeatability of supra-sternal Doppler (ultrasound cardiac output monitor) during general anaesthesia: effects of scan quality,

Monitoring level of sedation with bispectral EEG analysis: comparison between hypothermic and normothermic cardiopulmonary bypass† D. Schmidlin, P. Hager,

H.A. Leather, P.F. Wouters British Journal of Anaesthesia

Effects of dexmedetomidine on adrenocortical function, and the cardiovascular, endocrine and inflammatory responses in post-operative patients needing.

Fig 1 Iso‐MAC chart for isoflurane (age ≥1 yr)

Presentation transcript:

Xenon increases total body oxygen consumption during isoflurane anaesthesia in dogs O. Picker, A.W. Schindler, L.A. Schwarte, B. Preckel, W. Schlack, T.W.L. Scheeren, V. Tha¨mer British Journal of Anaesthesia Volume 88, Issue 4, Pages 546-554 (April 2002) DOI: 10.1093/bja/88.4.546 Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

Fig 1 Oxygen consumption (V˙o2) and cardiac output (CO) in the awake state, during isoflurane anaesthesia 1.4% and 2.8% and after adding 50% and 70% xenon to an isoflurane baseline. Data are mean±SEM from five dogs. Note the significant increase in V˙o2 (*P<0.05) in the presence of xenon compared with 1.4% isoflurane, whereas CO remained essentially unchanged. n.s., not significant. British Journal of Anaesthesia 2002 88, 546-554DOI: (10.1093/bja/88.4.546) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

Fig 2 Relationship between cardiac output (CO) and oxygen consumption (V˙o2) in the awake state (A) and during isoflurane anaesthesia (1.4% [B, C] and 2.8% [D]) in comparison with xenon anaesthesia (70% and 50% xenon with 1.4% isoflurane [E, F], 50% xenon with 0.7% isoflurane [G] and 70% xenon alone [H]). Values are given as mean±SEM from five dogs. Note the close relationship between V˙o2 and CO during the awake state and during isoflurane anaesthesia (open circles), as well as in the presence of xenon (closed circles), with different regression lines (P<0.05). British Journal of Anaesthesia 2002 88, 546-554DOI: (10.1093/bja/88.4.546) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

Fig 3 Sympathovagal balance analysed as heart rate variability in the frequency domain and expressed as high and low frequency normalized units (nuHF [squares] and nuLF [circles], respectively) during isoflurane anaesthesia ([open symbols] 1.4% [C], 2.8% [D]) and after adding xenon (70% and 50% [closed symbols] to 1.4% isoflurane [E, F]). Values are mean±SEM from five dogs. Note the parallel shift towards vagal activation (nuHF) when the anaesthetic depth is increased by adding xenon or by increasing the isoflurane alone. British Journal of Anaesthesia 2002 88, 546-554DOI: (10.1093/bja/88.4.546) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

Fig 4 Oxygen consumption (V˙o2) and cardiac output (CO) after ganglionic blockade with hexamethonium in the awake state, during 1.4% isoflurane anaesthesia alone and after adding 50% and 70% xenon to isoflurane baseline anaesthesia. Data are mean±SEM from five dogs. Note that V˙o2 increased (P<0.05), whereas CO remained almost unchanged (n.s., not significant), as in the absence of ganglionic blockade (compare with Fig. 1). British Journal of Anaesthesia 2002 88, 546-554DOI: (10.1093/bja/88.4.546) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

Fig 5 Arterial to mixed venous oxygen content difference (C(a– v ¯ )O2) during isoflurane anaesthesia (1.4% [C] and 2.8% [D]) in comparison with xenon anaesthesia (70% and 50% xenon with 1.4% isoflurane [E, F], 50% xenon with 0.7% isoflurane [G] and 70% xenon alone [H]) plotted against combined MAC. Data are mean±SEM from five dogs. Note that in the range above 1 MAC, C(a– v ¯ )O2 tended to increase with increasing anaesthetic depth in a parallel manner in the presence and absence of xenon. British Journal of Anaesthesia 2002 88, 546-554DOI: (10.1093/bja/88.4.546) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

Fig 6 Oxygen consumption (V˙o2 [diamonds]) and cardiac output (CO [circles]) in relation to the anaesthetic depth (MAC), in the awake state (A) and during isoflurane anaesthesia (1.4% [B, C] and 2.8% [D]) in comparison with xenon anaesthesia (70% and 50% xenon with 1.4% isoflurane [E, F], 50% xenon with 0.7% isoflurane [G] and 70% xenon alone [h]). Values are means from five dogs. Both variables correlate closely in the absence (open symbols) and presence (closed symbols) of xenon. Note that substituting xenon for parts of the isoflurane (see arrows) would lead to an increase in CO and V˙o2, with the effects of xenon tending to decrease as MAC increases. British Journal of Anaesthesia 2002 88, 546-554DOI: (10.1093/bja/88.4.546) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions