Urine Interleukin 18 and Lipocalin 2 Are Biomarkers of Acute Tubular Necrosis in Patients With Cirrhosis: A Systematic Review and Meta-analysis Jeremy.

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Presentation transcript:

Urine Interleukin 18 and Lipocalin 2 Are Biomarkers of Acute Tubular Necrosis in Patients With Cirrhosis: A Systematic Review and Meta-analysis Jeremy Puthumana, Xavier Ariza, Justin M. Belcher, Isabel Graupera, Pere Ginès, Chirag R. Parikh Clinical Gastroenterology and Hepatology Volume 15, Issue 7, Pages 1003-1013.e3 (July 2017) DOI: 10.1016/j.cgh.2016.11.035 Copyright © 2017 AGA Institute Terms and Conditions

Figure 1 Flow diagram of study selection. Clinical Gastroenterology and Hepatology 2017 15, 1003-1013.e3DOI: (10.1016/j.cgh.2016.11.035) Copyright © 2017 AGA Institute Terms and Conditions

Figure 2 Sensitivity and specificity of (A) urine IL18 and (B) urine NGAL for the diagnosis of ATN. Clinical Gastroenterology and Hepatology 2017 15, 1003-1013.e3DOI: (10.1016/j.cgh.2016.11.035) Copyright © 2017 AGA Institute Terms and Conditions

Figure 3 AUC of (A) urine IL18 and (B) urine NGAL for the diagnosis of ATN. Clinical Gastroenterology and Hepatology 2017 15, 1003-1013.e3DOI: (10.1016/j.cgh.2016.11.035) Copyright © 2017 AGA Institute Terms and Conditions

Figure 4 Sensitivity and specificity of (A) urine IL18 and (B) urine NGAL for predicting all-cause mortality. Clinical Gastroenterology and Hepatology 2017 15, 1003-1013.e3DOI: (10.1016/j.cgh.2016.11.035) Copyright © 2017 AGA Institute Terms and Conditions

Figure 5 AUC of (A) urine IL18 and (B) urine NGAL for predicting all-cause mortality. Clinical Gastroenterology and Hepatology 2017 15, 1003-1013.e3DOI: (10.1016/j.cgh.2016.11.035) Copyright © 2017 AGA Institute Terms and Conditions

Supplementary Figure 1 Funnel plots for the assessment of potential publication bias. (A) Urine IL18 for the diagnosis of ATN. (B) Urine NGAL for the diagnosis of ATN. (C) Urine IL18 for predicting all-cause mortality. (D) Urine NGAL for predicting all-cause mortality. dOR, diagnostic odds ratio. Clinical Gastroenterology and Hepatology 2017 15, 1003-1013.e3DOI: (10.1016/j.cgh.2016.11.035) Copyright © 2017 AGA Institute Terms and Conditions