Volume 146, Issue 4, Pages 970-979.e6 (April 2014) Baseline Values and Changes in Liver Stiffness Measured by Transient Elastography Are Associated With Severity of Fibrosis and Outcomes of Patients With Primary Sclerosing Cholangitis  Christophe Corpechot, Farid Gaouar, Ahmed El Naggar, Astrid Kemgang, Dominique Wendum, Raoul Poupon, Fabrice Carrat, Olivier Chazouillères  Gastroenterology  Volume 146, Issue 4, Pages 970-979.e6 (April 2014) DOI: 10.1053/j.gastro.2013.12.030 Copyright © 2014 AGA Institute Terms and Conditions

Figure 1 Box plot of LSM depending on histological fibrosis stage. The bottom and top of the boxes are the first and third quartiles (interquartiles), and the band inside the boxes is the median. The ends of the whiskers are the minimum and maximum of the data, and the horizontal stroke is the mean. Gastroenterology 2014 146, 970-979.e6DOI: (10.1053/j.gastro.2013.12.030) Copyright © 2014 AGA Institute Terms and Conditions

Figure 2 Scatter plots showing the correlations between the VCTE ratings (A) of 2 operators at the same measurement site and (B) those obtained by a single operator at 2 adjacent sites (seventh and eighth intercostal spaces). The ratings are presented on a logarithmic scale. Gastroenterology 2014 146, 970-979.e6DOI: (10.1053/j.gastro.2013.12.030) Copyright © 2014 AGA Institute Terms and Conditions

Figure 3 Changes in LSM as estimated by the linear mixed model (A) as a function of time and initial stage of fibrosis or (B) as a single continuous process extrapolated from the means of progression rates. Gastroenterology 2014 146, 970-979.e6DOI: (10.1053/j.gastro.2013.12.030) Copyright © 2014 AGA Institute Terms and Conditions

Figure 4 Survival rates without adverse outcomes according to different cutoff values of LSM (A–C) at baseline and (D–F) of LSM progression rate ΔLSM/∂t. LSM was strongly linked to risk of death, liver transplantation, or hepatic complications. Gastroenterology 2014 146, 970-979.e6DOI: (10.1053/j.gastro.2013.12.030) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 1 Box plot of LSM in the subgroup of patients with elevated bilirubin levels. Gastroenterology 2014 146, 970-979.e6DOI: (10.1053/j.gastro.2013.12.030) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 2 Receiver-operating characteristic curves of LSM, hyaluronic acid concentration, APRI score, FIB-4 score, and Mayo risk score for the diagnosis of (A) significant fibrosis (F2, F3, F4), (B) severe fibrosis (F3, F4), or (C) cirrhosis (F4). Gastroenterology 2014 146, 970-979.e6DOI: (10.1053/j.gastro.2013.12.030) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 3 Difference plot showing the difference between the ratings of 2 operators and the average of both ratings. The average (x-axis) is shown on a logarithmic scale. Thick dotted lines represent the 95% CI of the differences, and thin dotted lines represent the average and 95% CI of bias. Gastroenterology 2014 146, 970-979.e6DOI: (10.1053/j.gastro.2013.12.030) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 4 Spaghetti plot showing the individual changes in LSM observed in 146 patients with PSC. Each colored line corresponds to the course of LSM for a given subject. Gastroenterology 2014 146, 970-979.e6DOI: (10.1053/j.gastro.2013.12.030) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 5 Receiver-operating characteristic curves of changes in LSM (ΔLSM/∂t) and Mayo risk score (ΔMayo score/∂t) for the prediction of adverse outcomes (AUROC, 0.84 ± 0.06 and 0.83 ± 0.06, respectively; P = NS). Gastroenterology 2014 146, 970-979.e6DOI: (10.1053/j.gastro.2013.12.030) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 6 Box plots of (A) LSM and (B) ΔLSM/∂t in patients with or without an ALP level <1.5 times the upper limit of normal after at least 1 year of follow-up from diagnosis. Gastroenterology 2014 146, 970-979.e6DOI: (10.1053/j.gastro.2013.12.030) Copyright © 2014 AGA Institute Terms and Conditions