The CD8+ T cell repertoire is largely similar between the spleen and brain of the same lupus-prone animal. The CD8+ T cell repertoire is largely similar.

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The CD8+ T cell repertoire is largely similar between the spleen and brain of the same lupus-prone animal. The CD8+ T cell repertoire is largely similar between the spleen and brain of the same lupus-prone animal. (A–D) Venn-diagram analysis of CDR3 nucleotide sequence homology from three wild type B6 spleens (A), three TLR7tg spleens (B), three TLR7tg brains (C), and across all three groups (D) comparing in-frame reads. (E and F) CDR3 nucleotide sequence overlap across all in-frame reads of samples (n = 8) from indicated groups calculated by Morisita Index (E) and summarized for each group (F). Error bars indicate mean + SD. *p ≤ 0.05, ****p ≤ 0.0001, by Student t test. Peter A. Morawski, and Silvia Bolland ImmunoHorizons 2019;3:61-70 ©2019 by American Association of Immunologists