Nanopore Sequencing: Forcing Improved Resolution

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Nanopore Sequencing: Forcing Improved Resolution Derek Stein Biophysical Journal Volume 109, Issue 10, Pages 2001-2002 (November 2015) DOI: 10.1016/j.bpj.2015.10.003 Copyright © 2015 Biophysical Society Terms and Conditions

Figure 1 Influence of the applied force on the resolution of nanopore DNA sequencing. The schematic shows a DNA strand stalled in the sensitive constriction of an MspA nanopore under (a) a low applied force, which allows diffusion to shuffle the bases in the constriction; and (b) a high applied force, which suppresses fluctuations. To see this figure in color, go online. Biophysical Journal 2015 109, 2001-2002DOI: (10.1016/j.bpj.2015.10.003) Copyright © 2015 Biophysical Society Terms and Conditions