B. C. J. M. Fauser, P. Devroey, K. Diedrich, B. Balaban, M

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Presentation transcript:

Health outcomes of children born after IVF/ICSI: a review of current expert opinion and literature  B.C.J.M. Fauser, P. Devroey, K. Diedrich, B. Balaban, M. Bonduelle, H.A. Delemarre-van de Waal, C. Estella, D. Ezcurra, J.P.M. Geraedts, C.M. Howles, L. Lerner-Geva, J. Serna, D. Wells  Reproductive BioMedicine Online  Volume 28, Issue 2, Pages 162-182 (February 2014) DOI: 10.1016/j.rbmo.2013.10.013 Copyright © 2013 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 Odds ratios for birth defects after transfer of frozen and fresh IVF and ICSI early cleavage-stage embryos. ICSI=intracytoplasmic sperm injection (Belva et al., 2008; Källén et al., 2005). Reproductive BioMedicine Online 2014 28, 162-182DOI: (10.1016/j.rbmo.2013.10.013) Copyright © 2013 Reproductive Healthcare Ltd. Terms and Conditions

Figure 2 Biological factors influencing growth and development. Adapted from: Ceelen et al., 2008b. Reproductive BioMedicine Online 2014 28, 162-182DOI: (10.1016/j.rbmo.2013.10.013) Copyright © 2013 Reproductive Healthcare Ltd. Terms and Conditions

Figure 3 Results from a meta-analysis of five studies involving 4282 vitrified oocytes, 3524 fresh oocytes and 361 slow-frozen oocytes (2005–2009). Adapted from: Cobo and Diaz, 2011. Reproductive BioMedicine Online 2014 28, 162-182DOI: (10.1016/j.rbmo.2013.10.013) Copyright © 2013 Reproductive Healthcare Ltd. Terms and Conditions

Figure 4 Assisted reproduction treatment and potential alterations of the phenotypical fetal/adult programme. Reproductive BioMedicine Online 2014 28, 162-182DOI: (10.1016/j.rbmo.2013.10.013) Copyright © 2013 Reproductive Healthcare Ltd. Terms and Conditions

Figure 5 Stages of imprinting in early life. Adapted from: Gosden et al., 2003. Reproductive BioMedicine Online 2014 28, 162-182DOI: (10.1016/j.rbmo.2013.10.013) Copyright © 2013 Reproductive Healthcare Ltd. Terms and Conditions

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