Aprotinin and Dipyridamole for the Safe Reduction of Postoperative Blood Loss Gideon Cohen, Joan Ivanov, Richard D Weisel, Vivek Rao, Molly K Mohabeer,

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Aprotinin and Dipyridamole for the Safe Reduction of Postoperative Blood Loss Gideon Cohen, Joan Ivanov, Richard D Weisel, Vivek Rao, Molly K Mohabeer, Donald A.G Mickle The Annals of Thoracic Surgery Volume 65, Issue 3, Pages 674-683 (March 1998) DOI: 10.1016/S0003-4975(97)01428-8

Fig. 1 Patients in the dipyridamole group (DIP) had significantly more blood loss 12 hours postoperatively and were more likely to bleed excessively and receive a transfusion than patients in the dipyridamole and aprotinin group (DIP + APR). The Annals of Thoracic Surgery 1998 65, 674-683DOI: (10.1016/S0003-4975(97)01428-8)

Fig. 2 Women had lower preoperative hemoglobin values than men, and despite a similar incidence of excessive bleeding had a greater incidence of transfusions. (PRE-OP = preoperative.) The Annals of Thoracic Surgery 1998 65, 674-683DOI: (10.1016/S0003-4975(97)01428-8)

Fig. 3 Plasmin activity was lower in the dipyridamole and aprotinin group (DIP + APR) than in the dipyridamole group (DIP) at all times postoperatively. (PRE-OP = preoperative; POST-STERN = poststernotomy; END-CPB = termination of cardiopulmonary bypass after rewarming; 2 HRS POST-CPB = 2 hours after termination of cardiopulmonary bypass. The Annals of Thoracic Surgery 1998 65, 674-683DOI: (10.1016/S0003-4975(97)01428-8)

Fig. 4 Platelet count correlated inversely with bleeding time 2 hours postoperatively (r2 = 0.08; p < 0.01). The bleeding time tended to be lower in the dipyridamole and aprotinin group (DIP + APR) than in the dipyridamole group (DIP) at any given platelet count (top). Postoperative blood loss (at 12 hours) correlated directly with bleeding time at 2 hours postoperatively in the dipyridamole group (r2 = 0.20; p < 0.01), but not in the dipyridamole and aprotinin group (bottom). The Annals of Thoracic Surgery 1998 65, 674-683DOI: (10.1016/S0003-4975(97)01428-8)