Epithelial Sensing of Fungal Invasion

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Epithelial Sensing of Fungal Invasion Mihai G. Netea, Bart Jan Kullberg Cell Host & Microbe Volume 8, Issue 3, Pages 219-220 (September 2010) DOI: 10.1016/j.chom.2010.08.008 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 Differential Pathways of Epithelial Cell Activation by Colonizing Yeasts and Invading Hyphae Yeasts induce the NF-κB subunit p65 and early c-Jun activation in response to the yeast form of Candida albicans, which does not induce a cytokine response. In contrast, hyphae stimulate p65 and the early c-Jun activation, as well as the MAPK phosphatase MKP-1 and the late c-Fos response, resulting in a potent cytokine release. Cell Host & Microbe 2010 8, 219-220DOI: (10.1016/j.chom.2010.08.008) Copyright © 2010 Elsevier Inc. Terms and Conditions