Computed Tomography Findings Predicting Invasiveness of Thymoma

Slides:

Advertisements

Similar presentations

The evolution of treatment outcomes for resected stage IIIA non–small cell lung cancer over 16 years at a single institution Linda W. Martin, MD, Arlene.

Advertisements

Noriyasu Usami, MD, Shingo Iwano, MD, Kohei Yokoi, MD

Standard Report Terms for Chest Computed Tomography Reports of Anterior Mediastinal Masses Suspicious for Thymoma Edith M. Marom, MD, Melissa L. Rosado-de-Christenson,

Preoperative Chemo-Radiation-Induced Ulceration in Patients with Esophageal Cancer: A Confounding Factor in Tumor Response Assessment in Integrated Computed.

Thymic Epithelial Tumors: Prognostic Determinants Among Clinical, Histopathologic, and Computed Tomography Findings Jung Won Moon, MD, Kyung Soo Lee,

FDG PET-CT Aids in the Preoperative Assessment of Patients with Newly Diagnosed Thymic Epithelial Malignancies Marcelo F.K. Benveniste, MD, Cesar A.

Brett W. Carter, MD, Meinoshin Okumura, MD, Frank C

Next Generation Sequencing Uncovers Potential Genetic Driver Mutations of Malignant Pulmonary Granular Cell Tumor Song Xu, Qingchun Zhao, Sen Wei, Yi.

Suppurative Salmonella thyroiditis coexistence with invasive thymoma

Utility of PET, CT, and EUS to Identify Pathologic Responders in Esophageal Cancer Stephen G. Swisher, MD, Mary Maish, MD, Jeremy J. Erasmus, MD, Arlene.

Neoadjuvant chemoradiotherapy followed by surgery for esophageal adenocarcinoma: Significance of microscopically positive circumferential radial margins

Prognostic Significance of C-Reactive Protein and Smoking in Patients with Advanced Non-small Cell Lung Cancer Treated with First-Line Palliative Chemotherapy

Puja Gaur, MD, Wayne L. Hofstetter, MD, B

Lisa M. Brown, MD, MAS, David T. Cooke, MD, Elizabeth A. David, MD

Susan C. Scott, MD, Nathan A. Pennell, MD, PhD

Influence of Preoperative Radiation Field on Postoperative Leak Rates in Esophageal Cancer Patients after Trimodality Therapy Aditya Juloori, BS, Susan.

Application of the revised lung cancer staging system (IASLC Staging Project) to a cancer center population Edmund S. Kassis, MD, Ara A. Vaporciyan,

Phase II Trials of Imatinib Mesylate and Docetaxel in Patients with Metastatic Non-small Cell Lung Cancer and Head and Neck Squamous Cell Carcinoma Anne.

Histopathologic Response Criteria Predict Survival of Patients with Resected Lung Cancer After Neoadjuvant Chemotherapy Apar Pataer, MD, PhD, Neda Kalhor,

Non-Small Cell Lung Cancer Resection in Lymphoma Patients

Muhammad Umair Khawar, MD, Bhaskar Bhardwaj, MD, Himanshu Bhardwaj, MD

Lymph Node Ratio May Predict the Benefit of Postoperative Radiotherapy in Non– Small-Cell Lung Cancer Damien Urban, MBBS, B Med Sc, Jair Bar, MD, PhD,

Role of CT and PET Imaging in Predicting Tumor Recurrence and Survival in Patients with Lung Adenocarcinoma Ho Yun Lee, MD, PhD, So Won Lee, MD, Kyung.

Relationship Between Tumor Size and Survival in Non–Small-Cell Lung Cancer (NSCLC): An Analysis of the Surveillance, Epidemiology, and End Results (SEER)

Successful Treatment with Erlotinib after Gefitinib-Induced Severe Interstitial Lung Disease Masayuki Takeda, MD, PhD, Isamu Okamoto, MD, PhD, Chihiro.

Follow-Up of Patients after Stereotactic Radiation for Lung Cancer: A Primer for the Nonradiation Oncologist Kitty Huang, MSc, MDCM, David A. Palma,

Nomogram for Predicting the Risk of Invasive Pulmonary Adenocarcinoma for Pure Ground-Glass Nodules Lijie Wang, MD, Weiyu Shen, MD, Yong Xi, MD, Shuai.

Arun Rajan, MD, David Kotlyar, MD, Giuseppe Giaccone, MD, PhD

Preoperative Radiation Therapy and Chemotherapy for Pulmonary Blastoma: A Case Report Timothy M. Zagar, MD, Susan Blackwell, MHS, PA-C, Jeffrey Crawford,

The Role of Consolidation Therapy for Stage III Non-Small Cell Lung Cancer With Persistent N2 Disease After Induction Chemotherapy Arya Amini, BA, Arlene.

Phase II Randomized Study of Two Regimens of Sequentially Administered Mitomycin C and Irinotecan in Patients with Unresectable Esophageal and Gastroesophageal.

A Practical Guide of the Southwest Oncology Group to Measure Malignant Pleural Mesothelioma Tumors by RECIST and Modified RECIST Criteria Anne S. Tsao,

Edith M. Marom, MD, Carlos H. Martinez, MD, Mylene T

Patterns of Cardiac Perfusion Abnormalities After Chemoradiotherapy in Patients with Lung Cancer Isis W. Gayed, MD, H Helen Liu, PhD, Xiong Wei, MD,

Frank C. Detterbeck, MD, Andrew G

Results of T4 Surgical Cases in the Japanese Lung Cancer Registry Study: Should Mediastinal Fat Tissue Invasion Really be Included in the T4 Category?

Ellen Kim, MD, MPH, Siran Koroukian, PhD, Charles R. Thomas, MD

Disease Flare After Treatment Discontinuation in a Patient With EML4-ALK Lung Cancer and Acquired Resistance to Crizotinib Oana Pop, MD, Augustin Pirvu,

Massive Bronchogenic Cyst

Role of CT and PET Imaging in Predicting Tumor Recurrence and Survival in Patients with Lung Adenocarcinoma Ho Yun Lee, MD, PhD, So Won Lee, MD, Kyung.

Computed Tomography RECIST Assessment of Histopathologic Response and Prediction of Survival in Patients with Resectable Non–Small-Cell Lung Cancer after.

Clinicopathological Characteristics of Screen-Detected Lung Cancers

Respiratory dynamic magnetic resonance imaging for determining aortic invasion of thoracic neoplasms Yoo Jin Hong, MD, Jin Hur, MD, Hye-Jeong Lee, MD,

Results of T4 Surgical Cases in the Japanese Lung Cancer Registry Study: Should Mediastinal Fat Tissue Invasion Really be Included in the T4 Category?

Patterns of Failure, Toxicity, and Survival after Extrapleural Pneumonectomy and Hemithoracic Intensity-Modulated Radiation Therapy for Malignant Pleural.

The Role of Surgery in the Management of Primary Thymic Mucosa-associated Lymphoid Tissue (MALT) Lymphoma Kimihiro Shimizu, MD, PhD, Izumi Takeyoshi,

Anterior transpericardial approach for postchemotherapy residual midvisceral mediastinal mass in metastatic germ cell tumors Marc de Perrot, MD, Donna.

Stereotactic Body Radiation Therapy for Primary Lung Cancers >3 Centimeters John J. Cuaron, MD, Ellen D. Yorke, PhD, Amanda Foster, BA, Meier Hsu, MS,

Intrathoracic peripheral nerve sheath tumors in patients with neurofibromatosis type 1 (von Recklinghausen disease) Vijay S. Patel, MD, James D. St Louis,

“Salvage” Surgery for Primary Mediastinal Malignancies: Is it Worthwhile? Francesco Petrella, MD, Francesco Leo, MD, PhD, Giulia Veronesi, MD, Piergiorgio.

Noriyasu Usami, MD, Shingo Iwano, MD, Kohei Yokoi, MD

Role of Postoperative Radiotherapy in Nonlocalized Thymoma

Conditional Survival of Malignant Thymoma Using National Population-Based Surveillance, Epidemiology, and End Results (SEER) Registry (1973–2011) Ellen.

Association between Systemic Chemotherapy before Chemoradiation and Increased Risk of Treatment-Related Pneumonitis in Esophageal Cancer Patients Treated.

Pulmonary Resection for Metastases from Colorectal Cancer

Paraneoplastic Limbic Encephalitis Attributable to Thymoma

Antiangiogenesis Induced Tumor Cavitation in Lung Cancer

Extended Resections for Thymic Malignancies

Visceral Pleural Invasion Is Not Predictive of Survival in Patients With Lung Cancer and Smaller Tumor Size Elizabeth David, MD, Peter F. Thall, PhD,

Predictors of Recurrent Pulmonary Metastases and Survival After Pulmonary Metastasectomy for Colorectal Cancer Shanda H. Blackmon, MD, MPH, Elizabeth.

Tetsuzo Tagawa, MD, Miyuki Takasu, MD, Teruyoshi Ishida, MD

Follow-Up of Small (4 mm or Less) Incidentally Detected Nodules by Computed Tomography in Oncology Patients: A Retrospective Review Reginald F. Munden,

Stage III Thymic Epithelial Neoplasms are Not Homogeneous with Regard to Clinical, Pathological, and Prognostic Features Min-Woong Kang, MD, PhD, Eung-Sirk.

David Garfield, MD Journal of Thoracic Oncology

Jamie E. Chaft, MD, Camelia S. Sima, MD, MS, Michelle S

Farhood Farjah, MD, MPH, David R. Flum, MD, MPH, Scott D

Rogerio C. Lilenbaum, MD, John Cashy, PhD, Thomas A

Effect of Tumor Size on Prognosis in Patients Treated with Radical Radiotherapy or Chemoradiotherapy for Non–Small Cell Lung Cancer: An Analysis of the.

Improved Long-Term Outcome With Chemoradiotherapy Strategies in Esophageal Cancer Stephen G. Swisher, MD, Wayne Hofstetter, MD, Ritsuko Komaki, MD, Arlene.

Jenifer L. Marks, MD, Wayne Hofstetter, MD, Arlene M

Presentation transcript:

Computed Tomography Findings Predicting Invasiveness of Thymoma Edith M. Marom, MD, Miguel A. Milito, MD, Cesar A. Moran, MD, Ping Liu, MS, Arlene M. Correa, PhD, Edward S. Kim, MD, Ritsuko Komaki, MD, Jeremy J. Erasmus, MD, Wayne L. Hofstetter, MD, David C. Rice, MD, Stephen G. Swisher, MD Journal of Thoracic Oncology Volume 6, Issue 7, Pages 1274-1281 (July 2011) DOI: 10.1097/JTO.0b013e31821c4203 Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Fifty-nine-year-old woman with stage IIb thymoma. Contrast-enhanced chest computed tomography (CT) scan demonstrates a 4.5-cm anterior mediastinal mass (arrow) that is round, is well demarcated, and does not infiltrate the surrounding fat. At surgery, microscopic tumor invasion of the capsule was found. A, ascending aorta. P, main pulmonary artery. Journal of Thoracic Oncology 2011 6, 1274-1281DOI: (10.1097/JTO.0b013e31821c4203) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Sixty-one-year-old man with stage III thymoma. Contrast-enhanced chest computed tomography (CT) scan demonstrates an 8.5-cm anterior mediastinal mass (arrow) that is lobulated, is poorly demarcated, does not infiltrate the surrounding fat, and abuts <50% of the circumference of the ascending aorta (A). At surgery, the tumor was found to invade the pleura, lung parenchyma, and innominate vein. P, left pulmonary artery. Journal of Thoracic Oncology 2011 6, 1274-1281DOI: (10.1097/JTO.0b013e31821c4203) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 Nomogram to predict stage III/IV thymoma using computed tomography (CT) findings at presentation. The nomogram consists of six rows. Row 1 (points row) is the point assignment for each variable. Rows 2 to 4 correspond to the variables included in the model. For an individual patient, each variable in rows 2 to 4 is assigned a point value, which is determined by drawing a vertical line from the appropriate position on the variable row to the points row. The assigned points for all three variables are added, and the total is marked on row 5 (shaded row called: total points). Then, the probability of having stage III/IV disease is calculated by drawing a vertical line from the appropriate position on the total points row to the row 6, which shows the probability of stage III or IV disease. Thus, for a patient with a lobular, larger than 7 cm tumor, which infiltrates the surrounding fat, the points added would be 100, 55, and 63 points, respectively, which adds to 218 total points or a 75% probability of having stage III/IV disease. The concordance index of this nomogram is 0.804. After internal validation using 200 bootstrap samples, the bias-corrected concordance index was 0.795 with an optimism of 0.009. Using this point system, total points ≥164 predict a ≥50% probability of having stage III/IV disease. Journal of Thoracic Oncology 2011 6, 1274-1281DOI: (10.1097/JTO.0b013e31821c4203) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 4 Receiver operating characteristic curve of our nomogram showing that the nomogram predicts stage III/IV disease very well, with the area under the curve or concordance index of 80. Journal of Thoracic Oncology 2011 6, 1274-1281DOI: (10.1097/JTO.0b013e31821c4203) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 5 Kaplan-Meier estimate of progression-free survival according to the nomogram-predicted probability of having stage III/IV disease (p = 0.005). Journal of Thoracic Oncology 2011 6, 1274-1281DOI: (10.1097/JTO.0b013e31821c4203) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions