The central dogma Why might this be wrong or incomplete.

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Presentation transcript:

The central dogma Why might this be wrong or incomplete

RNA enzymes:

Ribosome

Self-splicing introns

Group II intron

The RNA world concept What arguments support an “RNA world” preceding a two biopolymer world?

Pro-RNA world RNA connects Information Storage (DNA) and catalysis (Protein) One could envision the DNA and protein polymers added to the RNA world RNA can be genetic material RNA can be an enzyme Many cofactors are ribonucleotides, which has been interpreted as a remnant from the RNA world

Contra-RNA world RNA is very reactive and instable (DNA is more stable) RNA catalysts are slow RNA is not a likely product of prebiotic synthesis The first self replicating RNA would need plenty of activated nucleotides. Even small contaminations with the stereoisomer kills replication. The primordial soup would have been too diluted -> primordial pizza (sandwich) reactants bound to surface