Co-occurrence network between taxa and biomarkers.

Slides:



Advertisements
Similar presentations
Effects of a caspase-1 inhibitor and NLRP3 inhibitor on nontypeable Haemophilus influenzae (NTHi)-induced interleukin (IL)-1β production. a) Peripheral.
Advertisements

Kaplan–Meier survival curves of interstitial pneumonia with autoimmune features (IPAF) with usual interstitial pneumonia (UIP) pattern (on high-resolution.
Pathological alterations in idiopathic pulmonary fibrosis (IPF).
Echocardiography view
Discoidin domain receptor (DDR)2 protein was highly expressed in the lungs of patients with interstitial lung disease (ILD). Discoidin domain receptor.
Translation from endotype to phenotype, variants and comorbidities.
Microbiomic changes during inhaled interferon (IFN)-γ
Flowchart for calculating the relative risk (RR) for cancer X and lung cancer (LC). Flowchart for calculating the relative risk (RR) for cancer X and lung.
Kaplan–Meier curves of 12-month survival after an index chronic obstructive pulmonary disease-related hospitalisation according to level of moderate and.
Kaplan–Meier curves for a, b) progression-free survival (PFS) and c, d) overall survival (OS) in a, c) large-cell neuroendocrine carcinoma patients and.
Prevalence of true-positive, false-negative and false-positive cases of chronic obstructive pulmonary disease identified with the fixed-limit Global Initiative.
Flow diagram of the systematic research method for detecting matching microRNAs (miRNAs) in systemic sclerosis (SSc) and idiopathic pulmonary fibrosis.
Symptoms measured by Edmonton Symptom Assessment Scale according to modified Medical Research Council (mMRC) dyspnoea scale groups. Symptoms measured by.
Kaplan–Meier curve for the time until the development of lung cancer in patients with idiopathic pulmonary fibrosis. Kaplan–Meier curve for the time until.
Distribution of lower extremity artery disease (LEAD) Fontaine stages over the combined chronic obstructive pulmonary disease (COPD) Global Initiative.
Effect of caspase-1 deficiency on lung inflammatory parameters and inflammatory cell subsets in a mouse model of asthma exacerbation. Effect of caspase-1.
MRNA expression of collagen-binding integrins in idiopathic pulmonary fibrosis (IPF) lungs. mRNA expression of collagen-binding integrins in idiopathic.
Representative images of immunohistochemical staining of discoidin domain receptor (DDR)2 in interstitial lung disease (ILD) other than idiopathic pulmonary.
Comparative expression of discoidin domain receptors (DDRs) between healthy lung tissues and those from different types of interstitial lung disease (ILD):
Bland–Altman comparison of lung clearance index (LCI) from multiple breath wash-out following open and modified closed circuit wash-in for both healthy.
Colocalisation of NLRP3 specks with cleaved interleukin (IL)-1β in bronchoalveolar lavage (BAL) macrophages, and nontypeable Haemophilus influenzae (NTHi)-stimulated.
Nitric oxide synthesised from alveolar macrophages reflects disease severity, and peripheral alveolar nitric oxide concentration (CANO) could be a noninvasive.
Maturation of recoded cystic fibrosis transmembrane conductance regulator (CFTR) channels. a) Representative Western blot obtained from HEK293 cells expressing.
A) In the presence of Aspergillus fumigatus, local IgA and IgG levels to A. fumigatus are significantly elevated; *: p
Flowchart showing the requirement for starting, documenting and evaluating the effect on quality of life (QoL) of interdisciplinary best supportive care.
Lung histopathology from two subjects demonstrating either capillaritis or prior alveolar haemorrhage. Lung histopathology from two subjects demonstrating.
Alveolar lymphangiogenesis is a feature of idiopathic pulmonary fibrosis (IPF). a) Tissue sections reacted with anti-D2-40 (brown) and anti-CD34 (red)
Kaplan–Meier survival curves of all-cause mortality in patients with idiopathic pulmonary fibrosis (IPF). Kaplan–Meier survival curves of all-cause mortality.
A white elephant or the elephant in the room
Health-related quality of life measured by the RAND 36-Item Health Survey according to modified Medical Research Council (mMRC) dyspnoea scale groups.
An audit of the post-hospitalisation pulmonary rehabilitation pathway in a northwest London hospital. An audit of the post-hospitalisation pulmonary rehabilitation.
Axial computed tomography (CT) images a) at baseline and b) at a 12-month follow-up scan, in a patient with idiopathic pulmonary fibrosis (IPF). b) Note.
Comparison of the bronchoalveolar lavage fluid (BALF) levels of the three vascular endothelial growth factor (VEGF) types in healthy volunteers and patients.
Box-plot of alpha-diversity measured by wholetree phylogenetic differences grouped according to sampling method and chronic obstructive pulmonary disease.
Mean taxonomic distribution at the phylum level, by sampling method, for all 125 individuals (unrarefied). Mean taxonomic distribution at the phylum level,
Most frequent words and phrases based on user comments about the registry. Most frequent words and phrases based on user comments about the registry. Word.
Schematic representation of the current evidence for the association of cadmium exposure with smoking-related lung disease including chronic obstructive.
Phosphorylation levels of discoidin domain receptor (DDR)2.
Concentration of inflammatory cytokines in epithelial lining fluid (ELF) were plotted for the normal control, smoker normal forced oscillation technique.
a) Factors influencing the risk of bleeding
Systems biology as a tool to improve idiopathic pulmonary fibrosis (IPF) treatment effectiveness. Systems biology as a tool to improve idiopathic pulmonary.
a) Mortality per time point (p<0
Scatter plot of the % change versus baseline in pulmonary function test results at a) 4 months and b) the end of the study versus the analyte concentration.
A family-based pulmonary rehabilitation (PR) programme enhanced the coping resources of the families of chronic obstructive pulmonary disease patients.
Evaluation of acute symptoms
Measurement of a) IL-8, b) IL-6 and c) GM-CSF release by BEAS-2B cells stimulated with deoxycholic acid for 48 h. Measurement of a) IL-8, b) IL-6 and c)
Comparison of the serum levels of the three vascular endothelial growth factor (VEGF) types in healthy volunteers and patients with idiopathic pulmonary.
The antifibrotic activity of pirfenidone in preclinical models of pulmonary fibrosis. a) Experimental design and effects of prophylactic pirfenidone treatment.
Time to disease progression or death in a) the whole Bosentan Use in Interstitial Lung Disease (BUILD)-1 study population and b) the subpopulation with.
Bacterial community comparison of samples with the most abundant bacterial families (>0.5% mean relative abundance). Bacterial community comparison of.
Proteinase activated receptor-1 expression in a) weak immunostaining in normal lung tissue, b) intense immunostaining in idiopathic pulmonary fibrosis,
Forest plot of adjusted odds ratios (with 95% confidence intervals) from multivariable multinomial logistic regression analysis (table 4), by number of.
Serum concentrations of procollagen type I C-peptide (PICP), Fas ligand, osteopontin (OPN) and matrix metalloproteinase (MMP)-7 in healthy controls (HCs)
Concordance of review article recommendations with contemporary guidelines. Concordance of review article recommendations with contemporary guidelines.
Categorisation of social media posts related to chronic obstructive pulmonary disease (COPD). #: based on article ID, social media link and/or content.
Differences in a) functional residual capacity (FRC) and b) lung clearance index (LCI) when using all trials in comparison with only the first two trials.
This schematic view of the morpho-functional unit of the lung (alveolus) depicts the main differences in cellular composition in idiopathic pulmonary fibrosis.
Distribution of patients in the first- or second-year follow-up according to the number of acute exacerbations of chronic obstructive pulmonary disease.
Proportion of participants with access to a, b) a radiologist and c, d) a pathologist experienced in interstitial lung diseases to discuss cases of suspected.
CXCL10/CXCR3 overexpression in invasive mucinous adenocarcinoma (IMA).
Bland–Altman comparison of functional residual capacity (FRC) measured from multiple breath wash-out following open and modified closed circuit wash-in.
Expression of genes related to inflammasome activation in peripheral blood mononuclear cell (PBMC) and bronchoalveolar lavage (BAL) macrophages. Expression.
Procedure for the diagnosis of interstitial lung diseases.
Investigation of suspected idiopathic pulmonary fibrosis: multidisciplinary team (MDT) discussion is a key component of the diagnostic pathway. Investigation.
Comparison of the serum and bronchoalveolar lavage fluid (BALF) levels of CCL21 among healthy volunteers and patients with idiopathic pulmonary fibrosis.
Transcriptomic fingerprint of advanced idiopathic pulmonary fibrosis (IPF) lung. Transcriptomic fingerprint of advanced idiopathic pulmonary fibrosis (IPF)
Hyperplastic alveolar epithelial type II cells show severe endoplasmic reticulum stress and consecutive apoptosis. Hyperplastic alveolar epithelial type.
Comparison of cancer-specific survival in patients with nonsmall cell lung cancer detected incidentally by computed tomography (CT) (n=41) or chest radiography.
Evaluation of exercise tolerance (6-min stepper test (6MST)), quality of life (Visual Simplified Respiratory Questionnaire (VSRQ)) and mood (Hospital Anxiety.
Effect of lipoxin A4 (LXA4) on alveolar type II cell (ATII) wound repair. Effect of lipoxin A4 (LXA4) on alveolar type II cell (ATII) wound repair. LXA4.
Presentation transcript:

Co-occurrence network between taxa and biomarkers. Co-occurrence network between taxa and biomarkers. Th: T-helper; IPF: idiopathic pulmonary fibrosis. compPLS was utilised to evaluate associations between the lung microbiome and local/systemic biomarkers, which were categorised as Th1, Th2, Th17 and/or IPF immunological phenotype. a) Associations between taxa and bronchoalveolar lavage (BAL) fluid cytokines. b) Associations between taxa and BAL cell supernatant cytokines. c) Associations between taxa and plasma cytokines. Negative associations are in red and positive associations are in grey; edge weight is scaled to represent the degree of confidence for the associations. Jing Wang et al. ERJ Open Res 2017;3:00008-2017 ©2017 by European Respiratory Society