Treating Leukemia in Youths

Slides:

Advertisements

Similar presentations

Survival Analysis In many medical studies, the primary endpoint is time until an event occurs (e.g. death, remission) Data are typically subject to censoring.

Advertisements

LEUKEMIA & LYMPHOMA SOCIETY TEAM IN TRAINING. THE LEUKEMIA & LYMPHOMA SOCIETY WORLDS LARGEST VOLUNTARY HEALTH ORGANIZATION DEDICATED TO FUNDING BLOOD.

Childhood Cancer Gabby Kulikowski & Kellie Campbell.

Basics of Pediatric Oncology Margret E. Merino, MD Pediatric Hematology/Oncology WRAMC.

(“Acute Lymphoblastic Leukemia in Children” par 1)

Epidemiology of Oral Cancer Module 1:. Epidemiology of Cancer, U.S.

Case for Support. Blood Cancers More than 1 million North Americans are fighting blood cancers, the third leading cause of cancer deaths. Early detection.

Cancer Staging.

INCIDENCE AND SURVIVAL TRENDS OF COLORECTAL CANCER FROM 2002 TO 2011 BE Ansa; E Alema-Mensah; MD Claridy; JQ Sheats; B Fontenot, and SA Smith Georgia Regents.

Breast Cancer: Treatment or Not? HFE 742 Cathy Simmons November 10, 2005.

High School Participation. Our Mission find cures for blood cancers The Leukemia & Lymphoma Society (LLS) exists to find cures for blood cancers and works.

Outcome of chemotherapy in synovial sarcoma (sys) patients (pts): review of 15 clinical trials from EORTCc involving advanced sys compared to other Soft.

Tools to Access the Latest Cancer Statistics Paul Miller Washington Reporting Fellowships program presentation April 15, 2013.

MULTIPLE MYELOMA Grant Support: National Center on Minority Health and Health Disparities, NIH (# P20MD002286). Francis Callwood BA.

Acknowledgements This report differs from the submitted abstract due to further subdivision of patients into analytic and non- analytic, and focus on the.

SEER Data Cancer Project Brett Langsjoen. SEER Surveillance, Epidemiology, and End Results Program of the National Cancer Institute (NCI) Purpose: Collect.

National Cancer Intelligence Network Outcome and the effect of age in 1318 patients with synovial sarcoma: Report from the National Cancer Intelligence.

Population-based study on the impact of familial form of Waldenström’s macroglobulinemia on overall survival Vilhjálmur Steingrímsson1, Sigrún Helga.

Accelerated radical radiotherapy for Non Small Cell Lung Cancer: Single centre audit outcome of two fractionations in the treatment of the elderly patients.

Figure S1. A B C Survival probability (%) P = 0.21 P = 0.37 P = 0.12

Tulsi Changulani 1,*, Jenny Bo 2, Mei-Ling Cheng 1, Andrew Tatham 1

NON-SMALL CELL LUNG CANCER

Cancer Statistics 2016 A Presentation from the American Cancer Society

Jun Li, MD MPH Epidemic Intelligence Service Officer

Cancer Statistics 2016 A Presentation from the American Cancer Society

Prognostic significance of tumor subtypes in male breast cancer:

Maury S et al. Proc ASH 2015;Abstract 1.

SD Walter MD1, T Mahten MD2, JW Harbour MD1,3

Presented By Deborah Schrag at 2016 ASCO Annual Meeting

National Resource Center for Late Effects after Cancer Treatment

Oncol Res Treat 2016;39: DOI: /

Copyright © 2003 American Medical Association. All rights reserved.

Non–Small Cell Lung Cancer at the Extremes of Age: Impact on Diagnosis and Treatment William C Nugent, MD, Mark T Edney, BA, Paul G Hammerness, BA, Bradley.

It is estimated that almost 1

Building better therapy for children with acute lymphoblastic leukemia

The use of high-dose cyclophosphamide, carmustine, and thiotepa plus autologous hematopoietic stem cell transplantation as consolidation therapy for high-risk.

A Clinical Evaluation of the International Lymphoma Study Group Classification of Non-Hodgkin's Lymphoma Blood Volume 89(11): June 1, 1997 ©1997.

In Stem Cell Transplantation by Limiting the Morbidity of Graft-versus-Host Disease Tolerance to Myeloablative Conditioning is Improved Nicolas Novitzky,

Comparison between Kaplan-Meier survival estimates of Bristol aortic valve surgery patients and the Monte Carlo-based generated Kaplan-Meier curve using.

5 Prevalence Ontario Cancer Statistics 2016 Chapter 5: Prevalence.

Supplemental Figure 1: Kaplan-Meier Curves of overall survival based on clinical stage at presentation and treatment modality Kaplan-Meier analyses depicting.

by Michael F. Leahy, and J. Harvey Turner

Shidan Wang, BS, Lin Yang, MD, Bo Ci, BS, Matthew Maclean, BS, David E

Estimated current cancer incidence

David J. Brenner, Eric J. Hall, Rochelle E. Curtis, Elaine Ron

Might Men Diagnosed with Metastatic Prostate Cancer Benefit from Definitive Treatment of the Primary Tumor? A SEER-Based Study Stephen H. Culp, Paul.

4155 primary hepatocellular carcinoma with known diagnosis month/year

Time from diagnosis to intensive chemotherapy initiation does not adversely impact the outcome of patients with acute myeloid leukemia by Sarah Bertoli,

Shih-Jen Hwang, Guillermina Lozano, Christopher I. Amos, Louise C

Anthony Lemaire, MD, William R

Improved Overall Survival with Aggressive Primary Tumor Radiotherapy for Patients with Metastatic Esophageal Cancer David M. Guttmann, MD, MTR, Nandita.

Published online September 20, 2017 by JAMA Surgery

Melanie H. Jacobson, M. P. H. , Ann C. Mertens, Ph. D. , Jessica B

Defining Optimal Comorbidity Measures for Patients With Early-Stage Non-small cell lung cancer Treated With Stereotactic Body Radiation Therapy Todd.

Non–Small Cell Lung Cancer at the Extremes of Age: Impact on Diagnosis and Treatment William C Nugent, MD, Mark T Edney, BA, Paul G Hammerness, BA, Bradley.

A Post Hoc Sensitivity Analysis of Survival Probabilities in a Multinational Phase III Trial of Decitabine in Older Patients With Newly Diagnosed Acute.

Role for XRT in treatment of early stage Follicular lymphoma?

Donor Cell Leukemia: A Review

GOCS GRUPO ONCOLÓGICO COOPERATIVO DEL SUR

The estimated survival function using the Cox proportional hazards model and the mean value covariate pattern (days to recurrence, net tumor volume) for.

NAACCR/IACR Combined Annual Conference 2019

Colorectal cancer survival disparities in California

Therapy-related acute myeloid leukaemia following treatment for cancer in childhood: a population-based registry study Introduction Acknowledge co-authors.

Jill S. Barnholtz-Sloan, PhD

A, Overall survival of patients treated with CAR T cells (black line; n = 15). A, Overall survival of patients treated with CAR T cells (black line; n.

by Jan J. Cornelissen, and Didier Blaise

by Lapo Alinari, and Kristie A. Blum

Overall survival of systemic mastocytosis patients.

Cold agglutinin disease

Overexpression of SUFU and GLI1 in the poor clinical outcome subgroup was confirmed by real-time PCR along with its association with disease progression.

Presentation transcript:

Treating Leukemia in Youths Zachary Smith and Theren Williams University of Michigan – Dearborn BACKGROUND METHODS RESULTS CONCLUSIONS National Cancer Institute SEER (1973-2014) Leukemia: cancer of the blood cell 3.5% of new cancer diagnoses 29% of new childhood cancer diagnoses 18,059 patients diagnosed between years 1973 and 2014 and from areas within the United States Contains primary sites in Leukemia and Hodgkin Lymphoma primarily Youth: ages 0 to 19 years old at diagnosis First 5 Years’ Survival Probability Analysis Probability of surviving 5 years after diagnosis (given treatment, age, etc.) Unreplicated Factorial Design with Type III ANOVA Survival Analysis Kaplan-Meier Survival Model Cox Proportional Hazard Model Chemotherapy significantly increases survival probability. Not all treatments were significant. Radiation alone was not significant. Chemotherapy alone had higher survival than radiation alone. Both treatments were not significantly higher in survival than either treatment alone. Age Group is significant. Ages 0-4 and 5-9 had higher survival probability (Leukemia Only). Patients of 10 years or older showed higher survival probability when treated by radiation (All Patients). Time period diagnosed is significant. Recent years have better survival. CoxPH with All (Base: Neither Treatment) Chemotherapy and Radiation significantly increase probability of surviving when given separately. Whereas, when given together it showed significantly lower survival. CoxPH with Leukemia Patients Only Chemotherapy showed significantly higher survival probability compared to Radiation and Both treatments. ACKNOWLEDGMENT UM-Dearborn scholar grant Advisors: Keshav Pokhrel and Taysseer Sharaf REFERENCES NCI. "SEER Data & Software." National Cancer Institute, Nov. 2016, https://seer.cancer.gov/data/. Accessed 3 Jan. 2018. CTCA. "Leukemia." Cancer Treatment Centers of America, 22 Feb. 2017, https://www.cancercenter.com/leukemia/stages/. Accessed 2 Feb. 2018. American Cancer Society, . "Cancer Facts & Figures 2018." American Cancer Society, 2018. Accessed 30 Apr. 2018