Significance of Ethnicity in the Risk of Acute Graft-versus-Host Disease and Leukemia Relapse after Unrelated Donor Hematopoietic Stem Cell Transplantation

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Presentation transcript:

Significance of Ethnicity in the Risk of Acute Graft-versus-Host Disease and Leukemia Relapse after Unrelated Donor Hematopoietic Stem Cell Transplantation Yasuo Morishima, Takakazu Kawase, Mari Malkki, Satoko Morishima, Stephen Spellman, Koichi Kashiwase, Shunichi Kato, Anne Cesbron, Jean-Marie Tiercy, David Senitzer, Andrea Velardi, Effie W. Petersdorf Biology of Blood and Marrow Transplantation Volume 19, Issue 8, Pages 1197-1203 (August 2013) DOI: 10.1016/j.bbmt.2013.05.020 Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Cumulative incidence of acute GVHD by ethnicity. (A) Grades II to IV acute GVHD; (B) grades III to IV acute GVHD. JJ, Japanese donor and patient pair; CC, white donor and patient pair; AfAf, African American donor and patient pair; HH, Hispanic donor and patient pair; API non-JJ, Asian/Pacific Islander donor and patients excluding Japanese pair; MM, mismatch race/ethnicity pair between donor and patients. Incidence of acute GVHD is shown in Supplemental Table S1. Biology of Blood and Marrow Transplantation 2013 19, 1197-1203DOI: (10.1016/j.bbmt.2013.05.020) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Survival after transplantation by ethnicity. (A) Patients with early status of leukemia at transplantation; (B) patients with advanced status of leukemia at transplantation. Early status: first and second CR of ALL or AML at transplantation, first CP of CML. Advanced status: more advanced status than early status. JJ, Japanese donor and patient pair; CC, white donor and patient pair; AfAf, African American donor and patient pair; HH, Hispanic donor and patient pair; API non-JJ, Asian/Pacific Islander donor and patients excluding Japanese pair; MM, mismatch ethnicity pair between donor and patients. Five-year survival rate after transplantation by ethnicity is provided in Supplemental Table S1. Biology of Blood and Marrow Transplantation 2013 19, 1197-1203DOI: (10.1016/j.bbmt.2013.05.020) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions