Life Is Short, if Sweet Cell Metabolism

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Life Is Short, if Sweet Cell Metabolism Jess Porter Abate, T. Keith Blackwell Cell Metabolism Volume 10, Issue 5, Pages 338-339 (November 2009) DOI: 10.1016/j.cmet.2009.10.006 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 Effects of Glucose on Insulin-like Signaling and Longevity Glucose stimulates release of insulin, which induces glucose uptake. Insulin-like signaling also inhibits FOXO/DAF-16, which positively regulates aqp-1 and other stress resistance and longevity genes. High glucose levels may increase cellular ROS. In C. elegans, these events all appear to occur in the intestine, although insulin-like signaling responses vary among tissues. Cell Metabolism 2009 10, 338-339DOI: (10.1016/j.cmet.2009.10.006) Copyright © 2009 Elsevier Inc. Terms and Conditions