Improving classification of melanocytic nevi: Association of BRAF V600E expression with distinct histomorphologic features Maija Kiuru, MD, PhD, Danielle.

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Presentation transcript:

Improving classification of melanocytic nevi: Association of BRAF V600E expression with distinct histomorphologic features Maija Kiuru, MD, PhD, Danielle M. Tartar, MD, PhD, Lihong Qi, PhD, Danyang Chen, MS, Lan Yu, BS, Thomas Konia, MD, John D. McPherson, PhD, William J. Murphy, PhD, Maxwell A. Fung, MD Journal of the American Academy of Dermatology Volume 79, Issue 2, Pages 221-229 (August 2018) DOI: 10.1016/j.jaad.2018.03.052 Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Histomorphologic features and B-Raf proto-oncogene, serine/threonine kinase (BRAF) V600E immunohistochemistry in melanocytic nevi. Junctional growth pattern (A) in a nevus with a negative BRAF V600E immunohistochemistry result (B). Dermal growth pattern (C) in a nevus with a positive BRAF V600E immunohistochemistry result (D). Congenital growth pattern involving adnexal epithelium (E) in a nevus with a positive BRAF V600E immunohistochemistry result (F). (A, C, and E, hematoxylin-eosin stain; original magnification ×200. B, D, and F, brown indicates positive staining, except for endogenous melanin in keratinocytes.) Journal of the American Academy of Dermatology 2018 79, 221-229DOI: (10.1016/j.jaad.2018.03.052) Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions