A dive into the complexity of type I interferon antiviral functions

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A dive into the complexity of type I interferon antiviral functions Maxime Touzot, Vassili Soumelis, Tarik Asselah Journal of Hepatology Volume 56, Issue 3, Pages 726-728 (March 2012) DOI: 10.1016/j.jhep.2011.07.009 Copyright © 2011 European Association for the Study of the Liver Terms and Conditions

Fig. 1 New view of ISG’s function in viral replication. Interferon stimulated genes (ISG) can be divided in 3 groups: strong inhibitors, modest inhibitors or enhancers. ISGs use multiple strategies to inhibit viral replication: either by targeting specific phase of viral replication (e.g. primary translational inhibition) or/and by potentiating IFN response by a positive feedback loop. IFNAR, Interferon receptor; ISRE, Interferon response stimulating elements, IRF9, Interferon response factor 9. Journal of Hepatology 2012 56, 726-728DOI: (10.1016/j.jhep.2011.07.009) Copyright © 2011 European Association for the Study of the Liver Terms and Conditions