Tetrodotoxin for Moderate to Severe Cancer Pain: A Randomized, Double Blind, Parallel Design Multicenter Study Neil A. Hagen, MD, FRCPC, Patrick du Souich,

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Presentation transcript:

Tetrodotoxin for Moderate to Severe Cancer Pain: A Randomized, Double Blind, Parallel Design Multicenter Study Neil A. Hagen, MD, FRCPC, Patrick du Souich, MD, PhD, Bernard Lapointe, MD, May Ong-Lam, MD, FRCPC, Benoit Dubuc, MD, David Walde, MD, FRCPC, Robin Love, MD, CCFP, Anh Ho Ngoc, PhD Journal of Pain and Symptom Management Volume 35, Issue 4, Pages 420-429 (April 2008) DOI: 10.1016/j.jpainsymman.2007.05.011 Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 1 Study design. Journal of Pain and Symptom Management 2008 35, 420-429DOI: (10.1016/j.jpainsymman.2007.05.011) Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 2 Average change in pain intensity after the subcutaneous administration of 30μg bid of TTX or placebo for four days in 36 and 37 patients, respectively. Journal of Pain and Symptom Management 2008 35, 420-429DOI: (10.1016/j.jpainsymman.2007.05.011) Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 3 Duration of analgesic response in the 14 patients who reported a ≥30% decrease in BPI#3, BPI#5, or in any of the three most bothersome pains. Journal of Pain and Symptom Management 2008 35, 420-429DOI: (10.1016/j.jpainsymman.2007.05.011) Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 4 Distribution according to the randomization to TTX or placebo, the type of pain (neuropathic and nonneuropathic) and the response to TTX and placebo. The percentages listed in the figure reflect the percentage of responders in the indicated treatment group. For example, 18% of patients with neuropathic pain who were administered placebo, responded to the treatment according to the predetermined primary endpoint. Journal of Pain and Symptom Management 2008 35, 420-429DOI: (10.1016/j.jpainsymman.2007.05.011) Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions