Volume 147, Issue 1, Pages (January 2015)

Slides:

Advertisements

Similar presentations

Volume 128, Issue 6, Pages (December 2005)

Advertisements

Tell-tale Telangiectasias

Colloquium on Therapy of Right Heart Failure

Volume 148, Issue 6, Pages (December 2015)

When to Be Rash About a Fever and Headache

Volume 102, Issue 3, Pages (September 1992)

Upper-Respiratory Viral Infection, Biomarkers, and COPD Exacerbations

Volume 136, Issue 6, Pages (December 2009)

Wan-Jie Gu, MSc, Chun-Yin Wei, MSc, Rui-Xing Yin, MD, PhD CHEST

Hyperbaric Oxygenation in Cardiac and Pulmonary Disease

Air Pollution and Chest Disease

Epidemiologic Studies of Air Pollution*

Navin K. Jain, MD, Thiam H. Lie, MD, FCCP CHEST

Volume 138, Issue 5, Pages (November 2010)

Volume 123, Issue 2, Pages (February 2003)

Clinical and Personality Profiles and Survival in Patients With COPD

Oxygen Therapy Titrated to Raise Mixed Venous Oxygen Content in COPD

Volume 128, Issue 4, Pages (October 2005)

Volume 113, Issue 4, Pages (April 1998)

Volume 148, Issue 5, Pages (November 2015)

Frank W. Ewald, MD, FCCP, Albert H. Scherff, MD CHEST

Volume 142, Issue 1, Pages (July 2012)

Volume 143, Issue 1, Pages (January 2013)

Volume 151, Issue 3, Pages (March 2017)

Prevalence of Pulmonary Embolism in Acute Exacerbations of COPD

COUNTERPOINT: Is the Apnea-Hypopnea Index the Best Way to Quantify the Severity of Sleep-Disordered Breathing? No Naresh M. Punjabi, MD, PhD, FCCP CHEST

Chronic Cough Due to Nonasthmatic Eosinophilic Bronchitis

Chronic Cough Due to Nonasthmatic Eosinophilic Bronchitis

Precision Medicine Urgency

Arterial Line or Cuff BP?

Spread the Word About CHEST in 2018

Probiotics for Prevention of Ventilator-Associated Pneumonia: Response

Biological clustering supports both “Dutch” and “British” hypotheses of asthma and chronic obstructive pulmonary disease Michael A. Ghebre, MSc, Mona.

Development of two real-time multiplex PCR assays for the detection and quantification of eight key bacterial pathogens in lower respiratory tract infections

Methicillin-Resistant Staphylococcus aureus Nosocomial Pneumonia

Airway Wall Expression of OX40/OX40L and Interleukin-4 in Asthma

Airway Stenting for Patients With Benign Airway Disease and the Food and Drug Administration Advisory Lund Mark E. , MD, FCCP, Force Seth , MD, FCCP

Role of airway glucose in bacterial infections in patients with chronic obstructive pulmonary disease Patrick Mallia, PhD, Jessica Webber, Simren K.

Point: Should Medicare Allow Respiratory Therapists to Independently Practice and Bill for Educational Activities Related to COPD? Yes Thomas M. Fuhrman,

Sundeep Salvi, MD, DNB, PhD, FCCP, Peter J. Barnes, DM, FCCP CHEST

Volume 145, Issue 2, Pages (February 2014)

Volume 104, Issue 1, Pages 1-2 (July 1993)

Imaging for the Management of Community-Acquired Pneumonia

Point: Should We Abandon FEV1/FVC <0

Spread the Word About CHEST in 2015

Possible Role of Statins in COPD-Related Pulmonary Hypertension

Volume 97, Issue 1, Pages (January 1990)

Brahms' Lullaby Revisited

Volume 149, Issue 1, Pages (January 2016)

Volume 138, Issue 4, Pages (October 2010)

JAMES A. KAUFMANN, M.D., F.C.C.P. Diseases of the Chest

Evolution in Reimbursement for Sleep Studies and Sleep Centers

Biological exacerbation clusters demonstrate asthma and chronic obstructive pulmonary disease overlap with distinct mediator and microbiome profiles

Volume 139, Issue 6, Pages (June 2011)

Bedside Calibration Of Pulmonary Artery Catheters

Invasive Pulmonary Aspergillosis

Pulmonary Manifestations in a Case of Multiple Myeloma

Do CIs Give You Confidence?

Effects of Beta-Adrenergic Agents on Hypokalemia

A Man in His 70s Presenting With Chest Pain and Hematuria

Volume 150, Issue 4, Pages (October 2016)

Volume 138, Issue 5, Pages (November 2010)

Synthetic Response of Stimulated Respiratory Epithelium

Counterpoint: Should Medicare Allow Respiratory Therapists to Independently Practice and Bill for Educational Activities Related to COPD? No Katherine.

David Bédard Méthot, MD, Évelyne Leblanc, MD, Yves Lacasse, MD CHEST

Systemic Inflammation, COPD, and Pulmonary Hypertension

Volume 138, Issue 5, Pages (November 2010)

Arterial Line or Cuff BP?

New Members of the Editorial Board

Rebuttal From Dr Kollef

Presentation transcript:

Volume 147, Issue 1, Pages 46-55 (January 2015) Association Between Pathogens Detected Using Quantitative Polymerase Chain Reaction With Airway Inflammation in COPD at Stable State and Exacerbations Bethan L. Barker, BMBS, Koirobi Haldar, MSc, Hemu Patel, BSc, Ian D. Pavord, MD, Michael R. Barer, PhD, Christopher E. Brightling, PhD, FCCP, Mona Bafadhel, PhD CHEST Volume 147, Issue 1, Pages 46-55 (January 2015) DOI: 10.1378/chest.14-0764 Copyright © 2015 The American College of Chest Physicians Terms and Conditions

Figure 1 Proportional Venn diagram depicting the distribution of qPCR codetection at baseline for all subjects. H. influenzae = Haemophilus influenzae; HI = Haemophilus influenzae; M. catarrhalis = Moraxella catarrhalis; MC = Moraxella catarrhalis; qPCR = quantitative polymerase chain reaction; S. pneumoniae = Streptococcus pneumoniae;SP = Streptococcus pneumoniae. CHEST 2015 147, 46-55DOI: (10.1378/chest.14-0764) Copyright © 2015 The American College of Chest Physicians Terms and Conditions

Figure 2 A-F, Correlations between the sputum mediator concentrations (A) TNFα, (B) IL1β, (C) IL8, (D) IL6, (E) IL10, and (F) CXCL10 and sputum bacterial load of HI, MC, and SP. TNF = tumor necrosis factor. See Figure 1 legend for expansion of other abbreviations. CHEST 2015 147, 46-55DOI: (10.1378/chest.14-0764) Copyright © 2015 The American College of Chest Physicians Terms and Conditions

Figure 3 A-F, Correlations between the sputum mediator concentrations (A) TNFα, (B) IL1β, (C) IL8, (D) IL6, (E) IL10, and (F) CXCL10 and sputum bacterial load of HI and MC in the subgroup of subjects qPCR positive for a single pathogen only. See Figure 1 and 2 legends for expansion of abbreviations. CHEST 2015 147, 46-55DOI: (10.1378/chest.14-0764) Copyright © 2015 The American College of Chest Physicians Terms and Conditions