Joint incongruity and biomarkers of bone metabolism as predictors of post-traumatic arthritis in mice T.J. Vovos, B.D. Furman, J.L. Huebner, K.A. Kimmerling,

Slides:

Advertisements

Similar presentations

Micro-CT bone structure evaluation in the Pond-Nuki dog model

Advertisements

C.-L. Wu, K. Kimmerling, D. Little, F. Guilak

Synovial mesenchymal stem cells from “super-healer” mice directly contribute to articular cartilage regeneration C.L. Jablonski, J. Mak, C. Leonard,

Extraction of anatomical landmarks and axis for 3D coordinate system construction of femur and tibia bone models X. Cui, H. Kim, S. Li, K.-S. Kwack,

Association of knee and ankle osteoarthritis with physical performance

Long-term periarticular bone adaptation in a feline knee injury model for post-traumatic experimental osteoarthritis S.K. Boyd, Ph.D., R. Müller, Ph.D.,

The groove model of osteoarthritis applied to the ovine fetlock joint

J.L. Huebner, M.S., V.B. Kraus, M.D., Ph.D.

K.S. Santangelo Osteoarthritis and Cartilage

Acute joint pathology and synovial inflammation is associated with increased intra- articular fracture severity in the mouse knee J.S. Lewis, W.C. Hembree,

Effects of intraarticular IL1-Ra for acute anterior cruciate ligament knee injury: a randomized controlled pilot trial (NCT ) V.B. Kraus, J. Birmingham,

M. Baharuddin, S.-H. Salleh, M. Lee, A. Mohd Noor

Transglutaminase 2 is a marker of chondrocyte hypertrophy and osteoarthritis severity in the Hartley guinea pig model of knee OA J.L. Huebner, K.A. Johnson,

Spatial and temporal changes of subchondral bone proceed to microscopic articular cartilage degeneration in guinea pigs with spontaneous osteoarthritis

Characterization of cartilage repair in a focal mouse defect model

K. A. Kimmerling, B. D. Furman, D. S. Mangiapani, M. A. Moverman, S. M

Characterisation of pain-related behaviours in association with joint pathology in an 8- week antigen-induced arthritis model S. Zaki, R.E. Miller, A.-M.

Osteoarthritis year 2011 in review: biochemical markers of osteoarthritis: an overview of research and initiatives Y. Henrotin Osteoarthritis and Cartilage

Demographic and biomechanical factors related to structural progression of hip osteoarthritis over 18 months D. Kumar, C. Wyatt, N. Okazaki, K. Chiba,

Correlation of non-destructive electromechanical probe (Arthro-BST) assessment with histological scores and mechanical properties in human tibial plateau

Change in bone area does not correlate with cartilage loss over 12 months in individuals with knee OA: Data from the osteoarthritis initiative M.A. Bowes,

A clinically realistic large animal model of intra-articular fracture that progresses to post- traumatic osteoarthritis J.E. Goetz, D. Fredericks, E.

D. R. Seifer, B. A. , B. D. Furman, M. S. , F. Guilak, Ph. D. , S. A

The effect of conditional macrophage depletion on development of injury-induced knee OA in obese transgenic MAFIA mice C.-L. Wu, J. McNeill, K. Goon,

Dietary fatty acids differentially affect the development of injury-induced osteoarthritis with diet-induced obesity in mice C.-L. Wu, D. Jain, D. Little,

Intra-articular corticosteroids may be a cost-effective strategy for short-term management of knee osteoarthritis R.R. Bannuru, J.B. Wong, D.M. Kent,

Spontaneous development of sclerotic changes of subchondral bone and cartilage degradation in endothelin-1 overexpression transgenic mice upon high fat/high.

Development of Asian hip stem 5 – Primary stability classification using time domain features and support vector machine M. Baharuddin, S.-H. Salleh,

Surface characterization of degenerated articular cartilage surface by contrast- enhanced micro-computed tomography T.J. Ylitalo, M. Finnilä, S. Karhula,

Y.Y. Leung, J.L. Huebner, B. Haaland, S.B.S. Wong, V.B. Kraus

Magnetic collection of joint-level osteoarthritis biomarkers

Evidence for articular cartilage regeneration in MRL/MpJ mice

Osteoarthritis and Cartilage

Water-soluble C60-(OH)24 fullerene hydroxide as a therapeutic agent against the degeneration of articular cartilage in osteoarthritis N. Yui, H. Yoshioka,

J. A. Gallagher, N. Thomas, J. L. Donnelly, N. Jeffery, D. Mills, G. R

N. Segal, E. Frick, M. Nevitt, J. Torner, D. Felson, A. Guermazi, D

Responsiveness of infra-patellar fat pad (IPFP) volume change with severe body weight gain and loss – Data from the OAI E. Steidle-Kloc, T. Dannhauer,

Regionally distinct f-actin networks within articular cartilage

C. -H. Chou, H. -G. Wisniewski, P. Band, J. Huebner, T. Stabler, C

Osteoarthritis and Cartilage

Optimizing methods to generate tissue engineered cartilage constructs under serum free conditions in suspension culture L.M. Allen, D. Ponjevic, J. Matyas,

M. Baharuddin, S.-H. Salleh, M. Lee, A. Mohd Noor

Z. Huang, T. Stabler, F. Pei, V. Kraus Osteoarthritis and Cartilage

Early Alterations in Articular Cartilage Surface topography in Post-traumatic Equine Model of Osteoarthritis S.M. Tabbaa, V.W. Wong, G. Silberman, C.W.

E. W. Bradley, L. R. Carpio, D. F. Amanatullah, S. Kakar, L. E. Ta, M

Y. Kaneko, T. Nozaki, H. Yu, K. Kaneshiro, R. Schwarzkopf, T. Hara, H

Walking with increased foot progression angle can reduce joint compression in individuals with knee OA K. Manal, T.S. Buchanan Osteoarthritis and Cartilage

A.B. Lovati, A. Pozzi, M. Bongio, C. Recordati, G. Berzero, M. Moretti

Osteoarthritis and Cartilage

Multivariate pattern analysis of physical activity and cartilage health: data from the osteoarthritis initiative E. Halilaj, T.J. Hastie, G.E. Gold,

R. O. Peterson, S. R. Hoy, L. M. Vucetich, J. A. Vucetich, V. B

3D modelling of the hip joint from clinical imaging data

Fracture severity predicts OA risk following intra-articular fractures

PIIANP and HELIXII diurnal variation

Cortical thickness mapping of the proximal femur: towards a new imaging biomarker of hip osteoarthritis T.D. Turmezei, G.M. Treece, A.H. Gee, K.E. Poole

Imaging biomarker with T1 and T2 mappings in osteoarthritis – In vivo human articular cartilage study C. Yan, C. Wong, T. Li, N. Gong, Q. Chan, K. Chiu

Nanoparticle targeting to cartilage: effects of surface charge on nanoparticle interactions with joint tissues S.B. Brown, B. Sharma Osteoarthritis.

The elastic modulus of articular cartilage at nano-scale and micro-scale measured using indentation type atomic force microscopy P. Rahnamay Moshtagh,

H. Khan, D. Aitken, C. Ding, L. Blizzard, J. -P. Pelletier, J

J.H. Ylärinne, C. Qu, M.J. Lammi Osteoarthritis and Cartilage

An intra-articular, extended release formulation of triamcinolone (FX006) affords clinically relevant improvements in pain and function of knee osteoarthritis:

Adhesive barrier/directional controlled release for cartilage repair by endogenous progenitor cell recruitment G.-I. Im, J.-M. Lee, E.-A. Kim Osteoarthritis.

Amyloid micronetworks for cartilage repair

Baseline magnetic resonance imaging cartilage T2 relaxation time measurements as predictors of total knee arthroplasty in African-Americans – Data from.

Concentrations of cytokines, matrix metalloproteinases, and tissue inhibitors of matrix metalloproteinases in autologous conditioned serum from horses.

Measurement of synovial fluid volume using urea

Fully automated segmentation of cartilage from magnetic resonance images using improved 3D shape context and active shape model T. Ye, X. Cui, H. Kim

Intra-articular delivery of kartogenin-conjugated chitosan nano/microparticles for cartilage regeneration G.-I. Im, M. Kang, J.-Y. Ko, J. Kim Osteoarthritis.

A. Carlson, B. Bothner, R. June Osteoarthritis and Cartilage

General Information Osteoarthritis and Cartilage

Presentation transcript:

Joint incongruity and biomarkers of bone metabolism as predictors of post-traumatic arthritis in mice T.J. Vovos, B.D. Furman, J.L. Huebner, K.A. Kimmerling, G.M. Utturkar, L.E. DeFrate, V.B. Kraus, F. Guilak, S.A. Olson Osteoarthritis and Cartilage Volume 23, Pages A242-A243 (April 2015) DOI: 10.1016/j.joca.2015.02.449 Copyright © 2015 Terms and Conditions

Figure 1(Top) Micro-CT images of representative fractures Figure 1(Top) Micro-CT images of representative fractures. (Bottom) Metrics of joint incongruity after intra-articular fracture. Reference surface = prefecture; test surface = post-fracture. Osteoarthritis and Cartilage 2015 23, A242-A243DOI: (10.1016/j.joca.2015.02.449) Copyright © 2015 Terms and Conditions

Figure 2(Top) Representative color map of axial deviation with fracture healing. (Bottom) Significant strain- wise differences in fracture healing to 8 weeks post- fracture (data with different letters are significantly different). Osteoarthritis and Cartilage 2015 23, A242-A243DOI: (10.1016/j.joca.2015.02.449) Copyright © 2015 Terms and Conditions

Figure 3. Correlations between total joint Mankin score for arthritis at 8 weeks post-fracture and post-fracture joint incongruity. Osteoarthritis and Cartilage 2015 23, A242-A243DOI: (10.1016/j.joca.2015.02.449) Copyright © 2015 Terms and Conditions

Figure 4. Serum concentrations of bone biomarkers PINP and CTX-I with articular fracture in C57BL/6 (B6) and MRL/MpJ (MRL) mice. Osteoarthritis and Cartilage 2015 23, A242-A243DOI: (10.1016/j.joca.2015.02.449) Copyright © 2015 Terms and Conditions