CYP19 gene: a genetic modifier of polycystic ovary syndrome phenotype

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CYP19 gene: a genetic modifier of polycystic ovary syndrome phenotype Nectaria Xita, M.D., Ph.D., Leandros Lazaros, Ph.D., Ioannis Georgiou, Ph.D., Agathocles Tsatsoulis, M.D., Ph.D. Fertility and Sterility Volume 94, Issue 1, Pages 250-254 (June 2010) DOI: 10.1016/j.fertnstert.2009.01.147 Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Difference of genotype distribution between patients grouped in quartiles according to total T levels and controls. SS = homozygous for short CYP19(TTTA)n alleles (nine or fewer repeats); SL = heterozygous for short CYP19(TTTA)n alleles; LL = homozygous for long CYP19(TTTA)n alleles (more than nine repeats). Fertility and Sterility 2010 94, 250-254DOI: (10.1016/j.fertnstert.2009.01.147) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Difference in T/E2 ratio between patients being homozygous (SS) for short CYP19(TTTA)n alleles (nine or fewer repeats) and patients being either heterozygous (SL) or homozygous (LL) for long CYP19(TTTA)n alleles (more than nine repeats). Fertility and Sterility 2010 94, 250-254DOI: (10.1016/j.fertnstert.2009.01.147) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions