DNA identification pathway

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Presentation transcript:

DNA identification pathway Lab Infer Evidence item Evidence data Evidence genotype 10, 12 10 12 Compare Known genotype 10, 12

Human interpretation issues • call good data inconclusive • peaks are too low for them • too many contributors to handle • potential examination bias

DNA pathway broken Lab Infer Evidence item Evidence data Evidence genotype ??? + Compare 7 10 12 14 Known genotype 10, 12

TrueAllele® Casework • preserve data information • use all peaks, high or low • any number of contributors • entirely objective, no bias • crime lab data, TrueAllele science

DNA pathway restored Lab Infer Evidence item Evidence data Evidence genotype 10, 10 @ 30% 10, 12 @ 50% 10, 14 @ 20% + 7 10 12 14 Compare Known genotype 10, 12

National DNA Mixture Crisis 375 cases/year x 4 years = 1,500 cases 320 M in US / 8 M in VA = 40 factor 1,500 cases x 40 factor = 60,000 inconclusive 1,000 cases/year x 4 years = 4,000 cases 320 M in US / 8 M in NY = 40 factor 4,000 cases x 40 factor = 160,000 inconclusive + underreporting of DNA match statistics DNA evidence data in 100,000 cases Collected, analyzed & paid for – but unused

DNA database pathway Evidence Reference Genotype database Match & Report Infer & Upload Crime scene Criminals

Old-style database issues • upload only 10% of mixtures • hit by association, not by match • comparison: make false hits • restrict upload: lose true hits

20th century DNA database Evidence Reference Allele database Allele database Match & Report Infer & Upload Crime scene Criminals +

TrueAllele® Database • upload all mixture evidence • hit based on LR match statistic • sensitive: find true hits • specific: only true hits • crime lab data, TrueAllele science

21st century DNA database Evidence Reference Genotype database Genotype database Match & Report Infer & Upload Crime scene Criminals +