Adiponectin Sparks an Interest in Calcium

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Adiponectin Sparks an Interest in Calcium Darren C. Henstridge, Mark A. Febbraio Cell Metabolism Volume 11, Issue 6, Pages 447-449 (June 2010) DOI: 10.1016/j.cmet.2010.05.007 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 Adiponectin-Mediated Oxidative Phenotype via AdipoR1 and Calcium Iwabu et al. (2010) propose that, in skeletal muscle, adiponectin induces extracellular Ca2+ influx by AdipoR1. This calcium influx sets off a chain of events whereby PGC1-α can be activated through both the CaMK pathway and via AMPK and SIRT1, leading to increased oxidative capacity. The mechanism by which adiponectin and AdipoR1 increase Ca2+ influx into cells remains to be fully determined. Cell Metabolism 2010 11, 447-449DOI: (10.1016/j.cmet.2010.05.007) Copyright © 2010 Elsevier Inc. Terms and Conditions