Meta-analysis of randomised controlled trials

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Meta-analysis of randomised controlled trials George Davey Smith, Matthias Egger The Lancet Volume 350, Issue 9085, (October 1997) DOI: 10.1016/S0140-6736(05)63833-0 Copyright © 1997 Elsevier Ltd Terms and Conditions

Figure Funnel plot of small trials, and meta-analyses of small trials and individual large trials of magnesium (upper) and streptokinase (lower) in acute myocardial infarction Circles=odds ratios (ORs) from trials included in meta-analysis; diamonds=combined odds ratios with 95% CIs from a meta-analysis; squares=ORs with 95% CIs from large trials appearing after the meta-analysis. The Lancet 1997 350, DOI: (10.1016/S0140-6736(05)63833-0) Copyright © 1997 Elsevier Ltd Terms and Conditions