DNA Hybridization Catalysts and Catalyst Circuits Georg Seelig, Bernard Yurke, and Erik Winfree, Preliminary Proceedings of Tenth International Meeting on DNA Computing, 152-161, (2004) MEC Seminar Su Dong Kim 27 JUL 2004

Algorithmic self-assembly of DNA Introduction ERROR RATE Biological Organism 10-9 Algorithmic self-assembly of DNA 1% ~ 10% Could we efficiently do catalytic reaction with a DNA hybridization catalyst?

Improving the DNA hybridization catalyst

Catalyst strand M catalyze the reaction of Fig 1c.

An AND-gate catalyst

Logic Gates and Circuits

Experimental Implementation (1)

Experimental Implementation (2)

Putative Reactions Taking Place