Impact of Asthma Exacerbations and Asthma Triggers on Asthma-related Quality of Life in Patients with Severe or Difficult-to-Treat Asthma Allan T. Luskin,

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Presentation transcript:

Impact of Asthma Exacerbations and Asthma Triggers on Asthma-related Quality of Life in Patients with Severe or Difficult-to-Treat Asthma Allan T. Luskin, MD, Bradley E. Chipps, MD, Lawrence Rasouliyan, MPH, Dave P. Miller, MS, Tmirah Haselkorn, PhD, Alejandro Dorenbaum, MD The Journal of Allergy and Clinical Immunology: In Practice Volume 2, Issue 5, Pages 544-552.e2 (September 2014) DOI: 10.1016/j.jaip.2014.02.011 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Figure 1 Increases in asthma exacerbation severity (A) and the number of exacerbations within the first year of follow-up (B) were associated with lower Mini-AQLQ domain scores at month 12. The total number of asthma exacerbations was based on HCU data collected at month 6 and month 12; 15 patients were excluded due to missing HCU data at month 12, with the remaining 2679 being included in the analysis. P values derived from 1-way ANOVA for differences in QoL scores within each Mini-AQLQ domain †(A) across asthma exacerbation severity categories or ∗(B) across the total number of asthma exacerbation. The Journal of Allergy and Clinical Immunology: In Practice 2014 2, 544-552.e2DOI: (10.1016/j.jaip.2014.02.011) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Figure 2 Association between baseline number of asthma triggers (symptoms from exposure to emotional stress, cold and/or sinus infection, pollen, animals, mold and/or dampness, or dust) and Mini-AQLQ domain scores at month 12. †Derived from 1-way ANOVA for differences in QoL scores within each Mini-AQLQ domain across the number of asthma triggers categories. The Journal of Allergy and Clinical Immunology: In Practice 2014 2, 544-552.e2DOI: (10.1016/j.jaip.2014.02.011) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Figure 3 Asthma exacerbation severity (A) and the number of exacerbations within the first year of follow-up (B) were associated with baseline number of asthma triggers (symptoms from exposure to emotional stress, cold and/or sinus infection, pollen, animals, mold and/or dampness, or dust). Asthma exacerbation severity and total number of asthma exacerbations were based on HCU data collected at month 6 and month 12; 15 patients were excluded due to missing HCU data at month 12; therefore, 2679 patients were included in this analysis. P < .001 for overall difference in the number of asthma triggers by asthma exacerbation severity or the total number of asthma exacerbations categories. The Journal of Allergy and Clinical Immunology: In Practice 2014 2, 544-552.e2DOI: (10.1016/j.jaip.2014.02.011) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Figure E1 Current analysis objectives. The Journal of Allergy and Clinical Immunology: In Practice 2014 2, 544-552.e2DOI: (10.1016/j.jaip.2014.02.011) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Figure E2 TENOR study enrollment criteria. *Daily high doses of inhaled steroids were defined by the American Thoracic Society Refractory Asthma Guidelines for Adults and by the National Heart Lung and Blood Institute guidelines for children Adapted from Chipps BE, Zeiger RS, Borish L, Wenzel SE, Yegin A, Hayden ML, et al. (Reference 21) The Journal of Allergy and Clinical Immunology: In Practice 2014 2, 544-552.e2DOI: (10.1016/j.jaip.2014.02.011) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Figure E3 The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement diagram for patient disposition. When analyzing the association between asthma severity and asthma-related QoL, baseline and month 6 HCU data were used, with 2694 patients included in the analysis. When analyzing the association between the total number of asthma exacerbations and asthma-related QoL, HCU data at month 6 and month 12 were used, with 2679 patients included in the analysis (15 patients had missing HCU data at month 12). The Journal of Allergy and Clinical Immunology: In Practice 2014 2, 544-552.e2DOI: (10.1016/j.jaip.2014.02.011) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions