Mechanisms of brain injury with deep hypothermic circulatory arrest and protective effects of coenzyme Q10 Ren Zhen, MD, Ding Wenxiang, MD, Su Zhaokang,

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Presentation transcript:

Mechanisms of brain injury with deep hypothermic circulatory arrest and protective effects of coenzyme Q10 Ren Zhen, MD, Ding Wenxiang, MD, Su Zhaokang, MD, Gu Xinling, MD, Huang Huiming, MD, Liu Jingfeng, MD, Yan Qing, MB, Zhang Weizhong, MB, Yu Xiaoqing, EB The Journal of Thoracic and Cardiovascular Surgery Volume 108, Issue 1, Pages 126-133 (July 1994) DOI: 10.5555/uri:pii:S0022522394702284 Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 1 ESR spectra changes in brain cortex (millimeters per milligram tissue). Spectrometer conditions of two groups were equal. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 126-133DOI: (10.5555/uri:pii:S0022522394702284) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 2 MDA changes in brain cortex (mean ± standard deviation). CA, Circulatory arrest. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 126-133DOI: (10.5555/uri:pii:S0022522394702284) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 3 Lactate changes in CSF (mean ± standard deviation). CA, Circulatory arrest. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 126-133DOI: (10.5555/uri:pii:S0022522394702284) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 4 Correlation between lactate and ATP. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 126-133DOI: (10.5555/uri:pii:S0022522394702284) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 5 Correlation between ATP and MDA. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 126-133DOI: (10.5555/uri:pii:S0022522394702284) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 6 Cell ultrastructure changes of the cerebral cortex during operation.A, At 60 minutes of circulatory arrest, the majority of mitochondria were swollen and showed vacuolization (magnification × 15,000). B, At 30 minutes of reperfusion, all mitochondria were swollen and showed vacuolization, and some lanthanum granules were entering the cytoplasm and mitochondria (magnification × 20,000). C, In the CoQ10 group and at 60 minutes of circulatory arrest, a part of the mitochondria were slightly swollen (magnification × 8000). D, In theCoQ10 group and at 30 minutes of reperfusion, mitochondria were slightly swollen without remarkable vacuolization. Lanthanum granules were rarely seen entering the cytoplasm (magnification × 17,000). The Journal of Thoracic and Cardiovascular Surgery 1994 108, 126-133DOI: (10.5555/uri:pii:S0022522394702284) Copyright © 1994 Mosby, Inc. Terms and Conditions