Mechanisms of brain injury with deep hypothermic circulatory arrest and protective effects of coenzyme Q10  Ren Zhen, MD, Ding Wenxiang, MD, Su Zhaokang,

Slides:



Advertisements
Similar presentations
Objective assessment of gastroesophageal reflux after short esophagomyotomy for achalasia with the use of manometry and pH monitoring John M. Streitz,
Advertisements

The additional hospital costs generated in the management of complications of pacemaker and defibrillator implantations T.Bruce Ferguson, MD, Candice Lilley.
Preoperative risk-of-death prediction model in heart surgery with deep hypothermic circulatory arrest in the neonate  Robert R. Clancy, MD, Susan A. McGaurn,
Vascular endothelial growth factor expression in non-small-cell lung cancer: Prognostic significance in squamous cell carcinoma  Hideyuki Imoto, MD, Toshihiro.
Lost in translation The Journal of Thoracic and Cardiovascular Surgery
Inhibition of microRNA-29c protects the brain in a rat model of prolonged hypothermic circulatory arrest  Yongchao Wang, MD, Tianxiang Gu, MD, PhD, Enyi.
Toshiharu Shin'oka, MDa, Dominique Shum-Tim, MD, MSca, Richard A
Prediction of severe acute kidney injury after pediatric cardiac surgery with the use of novel biomarkers: A new trend in clinical research and risk stratification 
Michael Zhen-Yu Tong, MBA, MD, Pavan Koka, MD, Thomas L. Forbes, MD 
Retrograde brain perfusion beyond the venous valves
Preoperative risk-of-death prediction model in heart surgery with deep hypothermic circulatory arrest in the neonate  Robert R. Clancy, MD, Susan A. McGaurn,
Cerebral metabolic recovery from deep hypothermic circulatory arrest after treatment with arginine and nitro-arginine methyl ester  Takeshi Hiramatsu,
B. Albat, MD, P. Messner-Pellenc, MD, A. Thévenet, MD 
Influence of oxygen in inflation gas during lung ischemia on ischemia-reperfusion injury  Atsushi Watanabe, MD, Nobuyoshi Kawaharada, MD, Katsuyuki Kusajima,
Cold retrograde cerebral perfusion improves cerebral protection during moderate hypothermic circulatory arrest: A long-term study in a porcine model 
Akihiko Ohkado, MD, Hung Cao-Danh, PhD, K. Eric Sommers, MD, Pedro J
Intrinsic cardiac stem cells are essential for regeneration
Cerebral protection during moderate hypothermic circulatory arrest: Histopathology and magnetic resonance spectroscopy of brain energetics and intracellular.
Comparison of neurologic outcome after deep hypothermic circulatory arrest with alpha- stat and pH-stat cardiopulmonary bypass in newborn pigs  Margaret.
Improved myocardial protection in minimally invasive aortic valve surgery with the assistance of port-access technology  Shubjeet Kaur, MDa, Jorge Balaguer,
Shigeyuki Sasaki, MD, PhD (by invitation), James D
David L. Reich, MD, Suzan Uysal, PhD, Martin Sliwinski, PhD, M
Inhibition of microRNA-29c protects the brain in a rat model of prolonged hypothermic circulatory arrest  Yongchao Wang, MD, Tianxiang Gu, MD, PhD, Enyi.
The lord of the rings  Antonio Miceli, MD, PhD 
Effect of esophageal distention on pressure and electromyographic activity of the pharyngoesophageal sphincter, with identification of the esophagopharyngeal.
Editorial: The core of leadership
Metabolic correlates of neurologic and behavioral injury after prolonged hypothermic circulatory arrest  Craig K. Mezrow, MSa, Alejandro Gandsas, MDa,
Jian Ye, MDa, Luojia Yang, MDa, Marc R
D. Loisance, MD, P. H. Deleuze, MD, J. P. Mazzucotelli, MD, Y
Primary repair of rupture of a main and lobar bronchus
Occult active giant cell aortitis necessitating surgical repair
Support Your Specialty
John A. Elefteriades, MD, PhD (hon), Bulat A. Ziganshin, MD, PhD 
T. Carrel, MD, M. Pasic, MD, U. Niederhäuser, MD, M. Turina, MD 
It's not “just a shunt” but sometimes it should be…
Cerebral hyperthermia during cardiopulmonary bypass in adults
Intermediate-Term Outcome Of Mitral Reconstruction In Cardiomyopathy
Elucidation of a tripartite mechanism underlying the improvement in cardiac tolerance to ischemia by coenzyme Q10 pretreatment  Juan A. Crestanello, MD.
Blood gas management and degree of cooling: Effects on cerebral metabolism before and after circulatory arrest  Lynne A. Skaryak, MDa, Paul J. Chai, MDa,
The Journal of Thoracic and Cardiovascular Surgery
Frederick L. Grover, MDa, b, David J
Patient recovery after intermittent disc escape and spontaneous recession of a mechanical heart valve  Francis Robicsek, MD, PhD, Joseph W. Cook, MD 
Addition Of A Mast Cell Stabilizing Compound To Organ Preservation Solutions Decreases Lung Reperfusion Injury  Mark L. Barr, MD, Joseph N. Carey, BS,
Ara K. Pridjian, MD, Edward L. Bove, MD, Flavian M. Lupinetti, MD 
Changes in whole blood lactate levels during cardiopulmonary bypass for surgery for congenital cardiac disease: An early indicator of morbidity and mortality 
Bidirectional Glenn procedure without cardiopulmonary bypass
Elspeth M. Brown, MRCP, Anthony P. Salmon, FRCP, Robert K. Lamb, FRCS 
Passing the torch The Journal of Thoracic and Cardiovascular Surgery
Effects of moderate versus deep hypothermic circulatory arrest and selective cerebral perfusion on cerebrospinal fluid proteomic profiles in a piglet.
Prognosis and “granularity”: Building on staging foundations?
The limits of detectable cerebral perfusion by transcranial doppler sonography in neonates undergoing deep hypothermic low-flow cardiopulmonary bypass 
Functional tricuspid pathology: To treat or not to treat
Postbypass effects of delayed rewarming on cerebral blood flow velocities in infants after total circulatory arrest  Rosendo A. Rodriguez, MD, PhDa (by.
The Journal of Thoracic and Cardiovascular Surgery
Discussion The Journal of Thoracic and Cardiovascular Surgery
Keep it short and sweet  Ian A. Makey, MD, Scott B. Johnson, MD 
The future of cardiac surgery training: A survival guide
Apparently, size matters…in congenital heart disease and brain injury
Postischemic hyperthermia exacerbates neurologic injury after deep hypothermic circulatory arrest  Dominique Shum-Tim, MDa, Mitsugi Nagashima, MDa, Toshiharu.
When should the elephant (frozen elephant trunk) enter the room (aorta)?  Frank A. Baciewicz, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume.
“The more things change…”: The challenges ahead
Toll-like receptor 4 inhibition attenuates ischemia-reperfusion injury in rats: Will it work in human beings?  Chadrick E. Denlinger, MD  The Journal.
Ryan R. Davies, MD  The Journal of Thoracic and Cardiovascular Surgery 
Minimally invasive direct coronary artery bypass, percutaneous transluminal coronary angioplasty, and stent placement for left main stenosis  William.
Samuel Kim, MD  The Journal of Thoracic and Cardiovascular Surgery 
Marek P. Ehrlich, MDa, Christian Hagl, MDa, Jock N
Carl L. Backer, MD, Bradley S. Marino, MD, MPP, MSCE 
Journal changes and initiatives
A prospective randomized study of neurocognitive function and S-100 protein after antegrade or retrograde brain perfusion with hypothermic arrest for.
S. Tabbutt, MD, PhDa b d e, B. W. Duncan, MDc f, D. McLaughlin, RNg, D
Presentation transcript:

Mechanisms of brain injury with deep hypothermic circulatory arrest and protective effects of coenzyme Q10  Ren Zhen, MD, Ding Wenxiang, MD, Su Zhaokang, MD, Gu Xinling, MD, Huang Huiming, MD, Liu Jingfeng, MD, Yan Qing, MB, Zhang Weizhong, MB, Yu Xiaoqing, EB  The Journal of Thoracic and Cardiovascular Surgery  Volume 108, Issue 1, Pages 126-133 (July 1994) DOI: 10.5555/uri:pii:S0022522394702284 Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 1 ESR spectra changes in brain cortex (millimeters per milligram tissue). Spectrometer conditions of two groups were equal. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 126-133DOI: (10.5555/uri:pii:S0022522394702284) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 2 MDA changes in brain cortex (mean ± standard deviation). CA, Circulatory arrest. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 126-133DOI: (10.5555/uri:pii:S0022522394702284) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 3 Lactate changes in CSF (mean ± standard deviation). CA, Circulatory arrest. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 126-133DOI: (10.5555/uri:pii:S0022522394702284) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 4 Correlation between lactate and ATP. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 126-133DOI: (10.5555/uri:pii:S0022522394702284) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 5 Correlation between ATP and MDA. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 126-133DOI: (10.5555/uri:pii:S0022522394702284) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 6 Cell ultrastructure changes of the cerebral cortex during operation.A, At 60 minutes of circulatory arrest, the majority of mitochondria were swollen and showed vacuolization (magnification × 15,000). B, At 30 minutes of reperfusion, all mitochondria were swollen and showed vacuolization, and some lanthanum granules were entering the cytoplasm and mitochondria (magnification × 20,000). C, In the CoQ10 group and at 60 minutes of circulatory arrest, a part of the mitochondria were slightly swollen (magnification × 8000). D, In theCoQ10 group and at 30 minutes of reperfusion, mitochondria were slightly swollen without remarkable vacuolization. Lanthanum granules were rarely seen entering the cytoplasm (magnification × 17,000). The Journal of Thoracic and Cardiovascular Surgery 1994 108, 126-133DOI: (10.5555/uri:pii:S0022522394702284) Copyright © 1994 Mosby, Inc. Terms and Conditions