Early detection of acute allograft rejection by linear and nonlinear analysis of heart rate variability Igor Izrailtyan, MDa, J.Yasha Kresh, PhDa, Rohinton.

Slides:

Advertisements

Similar presentations

The coronary delivery of marrow stromal cells for myocardial regeneration: Pathophysiologic and therapeutic implications Jih-Shiuan Wang, MD, Dominique.

Advertisements

Prevention of allograft heart valve failure in a rat model Jean-Francois Légaré, MDa,b, David B. Ross, MDa, Thomas B. Issekutz, MDa,b,c, Wendy Ruigrok,

Pathologic N1 non-small cell lung cancer: Correlation between pattern of lymphatic spread and prognosis Alessandro Marra, MD, PhD, Ludger Hillejan, MD,

Preoperative risk-of-death prediction model in heart surgery with deep hypothermic circulatory arrest in the neonate Robert R. Clancy, MD, Susan A. McGaurn,

Pathogenic structural heart changes in early tricuspid regurgitation

Society of Thoracic Surgeons 2008 cardiac risk models predict in-hospital mortality of heart valve surgery in a Chinese population: A multicenter study

The use of technetium tc 99m annexin V for in vivo imaging of apoptosis during cardiac allograft rejection Patrick W. Vriens, MDa, Francis G. Blankenberg,

Uz Stammberger, MDa, Jürg Hamacher, MDb, Sven Hillinger, MDc, Ralph A

Preoperative risk-of-death prediction model in heart surgery with deep hypothermic circulatory arrest in the neonate Robert R. Clancy, MD, Susan A. McGaurn,

Ludhmila A. Hajjar, MD, PhD, Juliano P. Almeida, MD, Julia T

Risk factors for early hospital readmission after cardiac operations

Centers for Disease Control “increased-risk” organ donor: Not so risky? Francis D. Pagani, MD, PhD The Journal of Thoracic and Cardiovascular Surgery

Silent myocardial ischemia in patients undergoing peripheral vascular surgery: Incidence and association with perioperative cardiac morbidity and mortality

Prediction of in-hospital mortality after ruptured abdominal aortic aneurysm repair using an artificial neural network Eric S. Wise, MD, Kyle M. Hocking,

William M. DeCampli, MD, PhD

Marye J. Gleva, MD, Charles B. Huddleston, MD

Assessment of pulmonary/systemic blood flow ratio after first-stage palliation for hypoplastic left heart syndrome Jack Rychik, MD, David M. Bush, MD,

Multiple Electrode Whole-Blood Aggregometry and Bleeding in Cardiac Surgery Patients Receiving Thienopyridines Marco Ranucci, MD, Ekaterina Baryshnikova,

Improved lung allograft function after fundoplication in patients with gastroesophageal reflux disease undergoing lung transplantation R.Duane Davis,

An economic evaluation of lung transplantation

Gain and subsequent loss of lung function after lung volume reduction surgery in cases of severe emphysema with different morphologic patterns Konrad.

Pediatric pacemaker infections: Twenty years of experience

Management of patients with intramural hematoma involving the ascending aorta Yoshimasa Moizumi, MDa, Tsunehiro Komatsu, MDa, Naotaka Motoyoshi, MDa,

Fresh porcine cardiac valves are not rejected in primates

Improvement of rejection-induced diastolic abnormalities in rat cardiac allografts with inducible nitric oxide synthase inhibition Pablo F. Soto, MDa,

Pulmonary vascular resistance after cardiopulmonary bypass in infants: Effect on postoperative recovery Ingram Schulze-Neick, MDa, Jia Li, MDa, Daniel.

Pathogenic structural heart changes in early tricuspid regurgitation

Shinichi Kanno, MD, PhDa, Paul C. Lee, MDb, Stephen J

Jaimin R. Trivedi, MD, MPH, Allen Cheng, MD, Michele Gallo, MD, Erin M

Aditya K. Kaza, MD The Journal of Thoracic and Cardiovascular Surgery

Newborn patients exhibit an unusual pattern of interleukin 10 and interferon γ serum levels in response to cardiac surgery A.J. Alcaraz, MDa*, L. Sancho,

Vivek Rao, MD, PhD, Mehmet C. Oz, MD, Margaret A

Support Your Specialty

Aggressive management of lung donors classified as unacceptable: Excellent recipient survival one year after transplantation Michaela Straznicka, MDa,

Scott B. Capps, MSa, Ronald C. Elkins, MDb, David M. Fronk, MSa

Bartley P. Griffith, MD, FACS, FRCS

Early and late outcomes of 517 consecutive adult patients treated with extracorporeal membrane oxygenation for refractory postcardiotomy cardiogenic shock

A first start for lung transplantation?

Pulmonary metabolism of endothelin 1 during on-pump and beating heart coronary artery bypass operations Patrick Mathieu, MDa, Jocelyn Dupuis, MD, PhDb,

Ability of bivariate cytokeratin and deoxyribonucleic acid flow cytometry to determine the biologic aggressiveness of resectable non–small cell lung cancer

M. Licker, A. Spiliopoulos, J.M. Tschopp

Despite some expression of folate receptor α in human mesothelioma cells, internalization of methotrexate is predominantly carrier mediated Nushmia Z.

Mark K. Ferguson, MD, Amy E. Durkin, MS, PA-C

Fueling the heart: Shifting the myocardial metabolome by targeting endothelial autophagy Nicholas D. Andersen, MD The Journal of Thoracic and Cardiovascular.

The use of argatroban as an anticoagulant for cardiopulmonary bypass in cardiac operations Kojiro Furukawa, MDa, Hitoshi Ohteki, MDa, Kenji Hirahara,

Tuberculous aneurysm of the descending thoracic aorta

Outcome of bilateral lung volume reduction in patients with emphysema potentially eligible for lung transplantation Bryan F. Meyers, MD, Roger D. Yusen,

Victor O. Morell, MDa, Jeffrey P. Jacobs, MDb, James A

Passing the torch The Journal of Thoracic and Cardiovascular Surgery

John H. Lemmer, MDa, George J. Despotis, MDb

Body weight and nutritional changes after reduction pneumoplasty for severe emphysema: A randomized study Tommaso Claudio Mineo, MDa, Vincenzo Ambrogi,

Quantitative analysis of continuous-wave Doppler spectral broadening for the diagnosis of carotid disease: Results of a multicenter study K.Wayne Johnston,

The role of a defined protocol for cardiac risk assessment in decreasing perioperative myocardial infarction in vascular surgery T.J. Bunt, MD Journal.

Cardiac transplant coronary artery disease: A multivariable analysis of pretransplantation risk factors for disease development and morbid events David.

Bilobectomy for massive hemoptysis after bilateral lung transplantation Stefan Guth, MDa, Eckhard Mayer, MDa, Berthold Fischer, MDb, Jana Lill, MDb, Norbert.

Human factors and cardiac surgery: A multicenter study

Jeffrey H. Shuhaiber, MD, Jeff Moore, MS, David B. Dyke, MD

The Journal of Thoracic and Cardiovascular Surgery

Discussion The Journal of Thoracic and Cardiovascular Surgery

Tai Ji: The law of inflammatory response

Second operation for upper mediastinal lymphadenopathy after complete resection for cancer of the left lung Masami Sato, MDa, b, Teruaki Koike, MDa,

The future of cardiac surgery training: A survival guide

Novel cerebral physiologic monitoring to guide low-flow cerebral perfusion during neonatal aortic arch reconstruction Dean B. Andropoulos, MDa, Stephen.

The effect of incentive spirometry and inspiratory muscle training on pulmonary function after lung resection Paltiel Weiner, MDa, Abraham Man, MDb,

Steven R. Gundry, MDa, Norihide Fukushima, MDa, Clifford C

Three-dimensional computed tomographic angiography as preoperative evaluation of a patent internal thoracic artery graft Atsushi Yamaguchi, MDa, Hideo.

A Risk Score to Predict Acute Renal Failure in Adult Patients After Lung Transplantation Joshua C. Grimm, MD, Cecillia Lui, BSE, Arman Kilic, MD, Vicente.

S. Fortier, MDa, R. G. Demaria, MD, PhDa,c, G. B. Pelletier, MDb, M

Similar neurobehavioral outcome after valve or coronary artery operations despite differing carotid embolic counts Michael J. Neville, MDa, John Butterworth,

Pulmonary transplantation for advanced bronchioloalveolar carcinoma

Presentation transcript:

Early detection of acute allograft rejection by linear and nonlinear analysis of heart rate variability Igor Izrailtyan, MDa, J.Yasha Kresh, PhDa, Rohinton J. Morris, MDb, Susan C. Brozena, MDb, Steven P. Kutalek, MDa, Andrew S. Wechsler, MDa The Journal of Thoracic and Cardiovascular Surgery Volume 120, Issue 4, Pages 737-745 (October 2000) DOI: 10.1067/mtc.2000.108930 Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 Left panels, HRV (R-R interval time series) plots in control and rejecting allografts spanning 800 consecutive beats. Right panels, The associated pointwise correlation dimension (PD2) metric computed for the respective patients. Note the loss in dimension (shift to the left) and the relatively narrowed PD2 histogram for the rejection-afflicted heart. The Journal of Thoracic and Cardiovascular Surgery 2000 120, 737-745DOI: (10.1067/mtc.2000.108930) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 Loss of spectral reserves in rejecting allografts. Composite graphs of power spectral density were computed by averaging individual patient spectra for rejecting (n = 11) and nonrejecting (n = 34) HTX groups by the maximum entropy method. The x-axis is scaled by the Nyquist critical frequency (reciprocal of twice the time interval between the average of R-R data points) for each respective group. LF, Low frequency; HF, high frequency. The Journal of Thoracic and Cardiovascular Surgery 2000 120, 737-745DOI: (10.1067/mtc.2000.108930) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 Receiver-operator characteristic (ROC) curves for the pointwise correlation dimension (PD2), low-frequency/high-frequency (LF/HF) ratio, time since transplantation, and scores from multivariable logistic regression model used in detecting myocardial rejection. The larger area under the curve (AUC) is indicative of the greater predictive value of PD2 analysis when compared with other univariate predictors. The Journal of Thoracic and Cardiovascular Surgery 2000 120, 737-745DOI: (10.1067/mtc.2000.108930) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 4 Representative phase-plane portraits (Poincare plots) of cardiac allograft R-R interval time series with and without rejection in route to and from complex (multifractal) dynamics. Compare the left panel complex (strange) attractor trajectory pattern to the simpler one (point-cluster in space) shown in the right panel . HTX, Heart transplantation; PD2, pointwise correlation dimension; ISHLT, International Society for Heart and Lung Transplantation. The Journal of Thoracic and Cardiovascular Surgery 2000 120, 737-745DOI: (10.1067/mtc.2000.108930) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions