Use of Neutrophil Count in Early Diagnosis and Risk Stratification of AMI Julia Meissner, MD, Affan Irfan, MD, Raphael Twerenbold, MD, Sandra Mueller,

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Use of Neutrophil Count in Early Diagnosis and Risk Stratification of AMI Julia Meissner, MD, Affan Irfan, MD, Raphael Twerenbold, MD, Sandra Mueller, Miriam Reiter, MD, Philip Haaf, MD, Tobias Reichlin, MD, Nora Schaub, MD, Katrin Winkler, MD, Otmar Pfister, MD, Corinna Heinisch, MD, Christian Mueller, MD The American Journal of Medicine Volume 124, Issue 6, Pages 534-542 (June 2011) DOI: 10.1016/j.amjmed.2010.10.023 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 White blood cell count, neutrophil count, neutrophil/lymphocyte ratio, and cardiac troponin T at presentation to the Emergency Department according to the adjudicated final diagnosis, acute myocardial infarction. Boxes represent interquartile ranges, while whiskers display ranges (without outliers further than 1.5 interquartile ranges from the end of the box). The American Journal of Medicine 2011 124, 534-542DOI: (10.1016/j.amjmed.2010.10.023) Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 2 (A) Receiver operating characteristic curves showing the diagnostic accuracy of cardiac troponin T, white blood cell count, neutrophil count, and neutrophil/lymphocyte ratio, and cardiac troponin T alone at presentation; and (B) in combination with white blood cell count, neutrophil count, and neutrophil/lymphocyte ratio to diagnose acute myocardial infarction in all patients. The American Journal of Medicine 2011 124, 534-542DOI: (10.1016/j.amjmed.2010.10.023) Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 3 (A) Diagnostic performance of white blood cell count, neutrophil count, neutrophil/lymphocyte ratio, and cardiac troponin T for acute myocardial infarction in patients presenting within 3 hours after the onset of symptoms. (B) Comparison of the area under the receiver operating characteristic (ROC) curve according to the time since the onset of symptoms for the 4 laboratory assays performed on blood samples obtained at presentation. The American Journal of Medicine 2011 124, 534-542DOI: (10.1016/j.amjmed.2010.10.023) Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 4 Kaplan-Meier plots for the cumulative event-free survival curves for long term for (A) white blood cell count, (B) neutrophil count, and (C) neutrophil/lymphocyte ratio tertiles, respectively. *Log-rank (Mantel-Cox) test of equality of survival distribution for the different levels of the white blood cell count, neutrophil count, and neutrophil/lymphocyte ratio tertiles (univariate analysis). The American Journal of Medicine 2011 124, 534-542DOI: (10.1016/j.amjmed.2010.10.023) Copyright © 2011 Elsevier Inc. Terms and Conditions