Makoto Hashizume, M. D. , Ph. D. , Yeng Yang, M. D. , Spencer Galt, M

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Presentation transcript:

Intimal response of saphenous vein to intraluminal trauma by simulated angioscopic insertion Makoto Hashizume, M.D., Ph.D., Yeng Yang, M.D., Spencer Galt, M.D., S.N.S. Murthy, Ph.D., Teruo Matsumoto, M.D., Ph.D. Journal of Vascular Surgery Volume 5, Issue 6, Pages 862-868 (June 1987) DOI: 10.1016/0741-5214(87)90100-5 Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 1 Prostacyclin production levels by low-damaged (LD, group A) and high-damaged (HD, group B) saphenous vein segments after angioscopic trauma. Basal production of prostacyclin significantly decreased in group B segments at day 1 (p < 0.05) and resumed to a normal level by 4 weeks postoperatively. Journal of Vascular Surgery 1987 5, 862-868DOI: (10.1016/0741-5214(87)90100-5) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 2 Scanning electron micrographs of saphenous vein surface (a-f, original magnification, ×1000). a, Control saphenous vein illustrates uniform endothelial cells, average appearance of microvilli, and distinct intercellular junctions. b, Group A segment at day 1: globular and contracted endothelial cells are found. c, Group B segment at day 1: endothelial cells are absent longitudinally and the luminal surface is covered with red blood cells and platelets. d, Group A segment at 2 weeks: regular flattened endothelial cells are found in all areas. e, Group B segment at 2 weeks: irregularly oriented, globular endothelial cells cover the luminal surface. f, Group B segment at 3 weeks: uniform, flattened endothelial cells are found in all areas. Journal of Vascular Surgery 1987 5, 862-868DOI: (10.1016/0741-5214(87)90100-5) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 3 Saphenous vein after simulated angioscopic insertion (a-d, hematoxylin-eosin stain ×248). a, Group A segment at day 1: a thin endothelial cell layer is recognized. b, Group B segment at day 1: endothelial cell layer is denuded and irregular surface is seen. c, Group B segment at 2 weeks: luminal surface is covered with cuboidal or spindle-shaped cell layer. d, Group B segment at 4 weeks: thin epithelial cell layer is seen. Journal of Vascular Surgery 1987 5, 862-868DOI: (10.1016/0741-5214(87)90100-5) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions