L.R. Peterson Clinical Microbiology and Infection

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Presentation transcript:

Currently available antimicrobial agents and their potential for use as monotherapy L.R. Peterson Clinical Microbiology and Infection Volume 14, Pages 30-45 (December 2008) DOI: 10.1111/j.1469-0691.2008.02125.x Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 1 Schematic diagram of various mechanisms of bacterial resistance. Adapted from reference [12]. Clinical Microbiology and Infection 2008 14, 30-45DOI: (10.1111/j.1469-0691.2008.02125.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 2 Comparison of time to defervescence in patients with persistent fever 48–60 h after initiation of empirical piperacillin–tazobactam monotherapy randomized to receive in addition either vancomycin or placebo. Median days (95% CI). p >0.5. Adapted from reference [14]. Clinical Microbiology and Infection 2008 14, 30-45DOI: (10.1111/j.1469-0691.2008.02125.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 3 Chemical structures of tetracycline, minocycline, and tigecycline. Adapted from references [16–18]. Clinical Microbiology and Infection 2008 14, 30-45DOI: (10.1111/j.1469-0691.2008.02125.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 4 Clinical cure rates in complicated skin and soft tissue infection (cSSTI) and complicated intra-abdominal infection (cIAI) phase 3 studies of tigecycline and comparators. Adapted from references [25,26]. Clinical Microbiology and Infection 2008 14, 30-45DOI: (10.1111/j.1469-0691.2008.02125.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 5 Schema of patients in studies of tigecycline vs. vancomycin–aztreonam (V/A) in the treatment of skin and skin structure infections. ITT, intent-to-treat; mITT, modified intent-to-treat. Adapted from reference [26]. Clinical Microbiology and Infection 2008 14, 30-45DOI: (10.1111/j.1469-0691.2008.02125.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 6 Cure rates by pathogen in the microbiologically evaluable population of the complicated skin and skin structure studies (tigecycline vs. vancomycin–aztreonam). MSSA, methicillin-susceptible Staphylococcus aureus; MRSA, methicillin-resistant S. aureus. aStreptococcus spp. includes S. anginosus, S. intermedius, and S. constellatus. Adapted from reference [26]. Clinical Microbiology and Infection 2008 14, 30-45DOI: (10.1111/j.1469-0691.2008.02125.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 7 Schema of patients in studies of tigecycline vs. imipenem–cilastatin (I/C) in the treatment of complicated intra-abdominal infections. ITT, intent-to-treat; mITT, modified intent-to-treat. Adapted from reference [25]. Clinical Microbiology and Infection 2008 14, 30-45DOI: (10.1111/j.1469-0691.2008.02125.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 8 Cure rates by diagnosis in the microbiologically evaluable population of the complicated intra-abdominal infection studies (tigecycline vs. imipenem–cilastatin) Adapted from reference [25]. Clinical Microbiology and Infection 2008 14, 30-45DOI: (10.1111/j.1469-0691.2008.02125.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions