Geoffrey J. Gorse, MD, Mary M. Donovan, MSN, Gira B

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Coronavirus and Other Respiratory Illnesses Comparing Older with Young Adults Geoffrey J. Gorse, MD, Mary M. Donovan, MSN, Gira B. Patel, MS, Sumitra Balasubramanian, MS, Rodney H. Lusk, MD The American Journal of Medicine Volume 128, Issue 11, Pages 1251.e11-1251.e20 (November 2015) DOI: 10.1016/j.amjmed.2015.05.034 Copyright © 2015 Terms and Conditions

Figure 1 Acute respiratory illnesses evaluated by calendar quarter. (A) Shown are the numbers of enrolled study subjects who were being actively followed in the study for acute respiratory illnesses by calendar quarter and the numbers of illnesses, in association with viral infection or not, with onset during each calendar quarter. (B) Shown are the numbers of enrolled subjects who were being actively followed in the study for acute respiratory illnesses by calendar quarter when more than 20 subjects were actively enrolled. The incidence rates of acute respiratory illness, calculated as illnesses per patient per year, are shown by calendar quarter and association with viral infection or not. Comparisons of categoric variables were by 2-sided Fisher exact test. The “All Illnesses” line includes the 95% confidence interval of the incidence rate for each calendar quarter. aP < .05, incidence of illnesses not associated with a virus infection was highest in the fourth quarter of 2010 compared with the third quarter of 2010 and first quarter of 2011. bP < .05, incidence of illnesses not associated with a virus infection was higher in the first quarter of 2012 compared with the second quarter of 2012. cP < .05, incidence of illnesses associated with all virus infections was highest in the second quarter of 2012 compared with the first and third quarters of 2012. dP < .05, eP < .05, incidence of all illnesses was higher in the first quarter of 2010 compared with the second and third quarters of 2010. fP < .05, incidence of all illnesses was higher in the fourth quarter of 2010 compared with the third quarter of 2010. gP < .05, incidence of all illnesses was higher in the fourth quarter of 2011 compared with the first quarter of 2012. hP < .05, incidence of all illnesses was higher in the second quarter of 2012 compared with the third quarter of 2012. The American Journal of Medicine 2015 128, 1251.e11-1251.e20DOI: (10.1016/j.amjmed.2015.05.034) Copyright © 2015 Terms and Conditions

Figure 2 The number of illnesses with each symptom and the maximum symptom severity during each illness are shown by severity grade (mild, moderate or severe), subject age group, and association of illness with viral infection or not. Data for maximum severity were not available for 1 illness in group 1 and 11 illnesses in group 2. The height of each vertical bar is the number of illnesses with that symptom. The percentage of illnesses with that symptom is plotted with each vertical bar, respectively. Comparisons of categoric variables were by 2-sided Fisher exact test. (A) Maximum systemic illness symptoms in group 1, chronically ill, older adults aged ≥60 years. aP < .01, myalgias were more common in patients with viral infection other than coronaviruses compared with illnesses with a coronavirus infection. (B) Maximum systemic illness symptoms in group 2 healthy, young adults aged 18 to 40 years. (C) Maximum local/respiratory illness symptoms in group 1 chronically ill, older adults, aged ≥60 years. (D) Maximum local/respiratory illness symptoms in group 1 healthy, young adults aged 18 to 40 years. aP < .01, cough was more common among patients with an illness not associated with a virus infection compared with those associated with coronavirus infection. The American Journal of Medicine 2015 128, 1251.e11-1251.e20DOI: (10.1016/j.amjmed.2015.05.034) Copyright © 2015 Terms and Conditions