I. Introduction American Journal of Kidney Diseases

Slides:



Advertisements
Similar presentations
Robert M. Guthrie, MD Professor of Emergency Medicine
Advertisements

ALLHAT 6/5/ CARDIOVASCULAR DISEASE OUTCOMES IN HYPERTENSIVE PATIENTS STRATIFIED BY BASELINE GLOMERULAR FILTRATION RATE (3 GROUPS by GFR)
6/5/ CARDIOVASCULAR DISEASE OUTCOMES IN HYPERTENSIVE PATIENTS STRATIFIED BY BASELINE GLOMERULAR FILTRATION RATE (4 GROUPS by GFR) ALLHAT.
Date of download: 6/23/2016 From: Screening for, Monitoring, and Treatment of Chronic Kidney Disease Stages 1 to 3: A Systematic Review for the U.S. Preventive.
Efficacy and safety of the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab among high cardiovascular risk patients on maximally tolerated.
Figure 1.1 Prevalence of CKD by stage among NHANES participants,
The LIVES Sub-analysis
The SPRINT Research Group
Implementing KDOQI CKD Definition and Staging Guidelines in Southern California Kaiser Permanente  Mark Rutkowski, MD, Wendy Mann, PharmD, Stephen Derose,
Michael J. Koren, MD, Michael H. Davidson, MD, Daniel J
LDL cholesterol in CKD—to treat or not to treat?
Robert C. Stanton, MD  American Journal of Kidney Diseases 
Chronic Kidney Disease in Diabetes
Chapter 1: CKD in the General Population
Copyright © 2002 American Medical Association. All rights reserved.
V. Atella, A. Brady, A. L. Catapano, J. Critchley, I. M. Graham, F. D
Copyright © 2012 American Medical Association. All rights reserved.
Classification of total cholesterol levels
Volume 67, Pages S1-S7 (June 2005)
Effects of High Density Lipoprotein Raising Therapies on Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus, with or without Renal Impairment:
CPR 1.1. Identifying Patients and Initiating Evaluation
Diabetes and Dyslipidemia
Renal function and outcome after heart transplantation
Martin W. Schoen, MD, MPH, Joanne Salas, MPH, Jeffrey F
American Journal of Kidney Diseases 
Baseline characteristics of HPS participants by prior diabetes
Estimating GFR Using the CKD Epidemiology Collaboration (CKD-EPI) Creatinine Equation: More Accurate GFR Estimates, Lower CKD Prevalence Estimates, and.
A: Epidemiology update
KDOQI Clinical Practice Guideline for Diabetes and CKD: 2012 Update
Chapter 1: CKD in the General Population
Kostas C. Siamopoulos, MD, FRSH, Chariklia Gouva, MD, Konstantinos P
A Decade After the KDOQI CKD Guidelines
Volume 68, Issue 2, Pages (August 2005)
Joseph A. Vassalotti, MD, Beth Piraino, MD, Lynda A. Szczech, MD 
Fellström BC, et al. N Engl J Med 2009;360:1455-7
Chronic Kidney Disease in Diabetes
II. assessment of dyslipidemias
Volume 80, Issue 1, Pages (July 2011)
Susumu Takahashi, Kazuyoshi Okada, Mitsuru Yanai  Kidney International 
Advances in CKD Detection and Determination of Prognosis: Executive Summary of the National Kidney Foundation–Kidney Early Evaluation Program (KEEP) 2012.
Assessment of statin therapy, LDL-C levels, and cardiovascular events among high-risk patients in the United States  Sudhir K. Unni, PhD, MBA, Ruben G.W.
Your Kidneys May Outlive You
Meeting the challenges of the new K/DOQI guidelines
J-Shaped Mortality Relationship for Uric Acid in CKD
Guidelines for the Older Adult With CKD
Contemporary Evidence-Based Guidelines
The risk of cardiovascular events with increased apolipoprotein CIII: A systematic review and meta-analysis  Moritz C. Wyler von Ballmoos, MD, MPH, Bernhard.
Robert C. Stanton, MD  American Journal of Kidney Diseases 
Attainment of low-density lipoprotein cholesterol goal after endovascular treatment is associated with reduced cardiovascular events in patients with.
American Journal of Kidney Diseases
LDL cholesterol in CKD—to treat or not to treat?
Beef Tea, Vitality, Creatinine, and the Estimated GFR
Aggressive blood pressure reduction and renin–angiotensin system blockade in chronic kidney disease: time for re-evaluation?  Pantelis A. Sarafidis, Luis.
Effectiveness of Pharmacist Interventions on Cardiovascular Risk in Patients With CKD: A Subgroup Analysis of the Randomized Controlled RxEACH Trial 
Cardiovascular complications in chronic kidney disease
American Journal of Kidney Diseases
Evidence and Outcomes in CKD
The Association of Lipid-Modifying Medications With Mortality in Patients on Long-Term Peritoneal Dialysis  Alexander S. Goldfarb-Rumyantzev, MD, PhD,
Dennis G. Moledina, MD, Mark A. Perazella, MD 
Daniel E. Weiner, MD, MS, Mark J. Sarnak, MD, MS 
Methods for guideline development
Volume 87, Issue 1, Pages (January 2015)
KDOQI Clinical Practice Guideline and Clinical Practice Recommendations for Anemia in Chronic Kidney Disease: 2007 Update of Hemoglobin Target    American.
ACE inhibition is effective and renoprotective in hypertensive nephrosclerosis: The African American Study of Kidney Disease and Hypertension (AASK) trial 
Intensive Lowering of Low-Density Lipoprotein Cholesterol Levels for Primary Prevention of Coronary Artery Disease  Dean G. Karalis, MD  Mayo Clinic Proceedings 
Giuseppe Remuzzi, Carlos Chiurchiu, Piero Ruggenenti 
III. Treating dyslipidemias
Lipids, the Heart, and the Kidney
A Decade After the KDOQI CKD Guidelines: Impact on the National Kidney Foundation's Kidney Early Evaluation Program (KEEP)  Adam Whaley-Connell, DO, MSPH 
International Journal of Cardiology
Presentation transcript:

I. Introduction American Journal of Kidney Diseases   American Journal of Kidney Diseases  Volume 41, Pages S11-S21 (April 2003) DOI: 10.1016/S0272-6386(03)00119-7

Fig 1 The evolution of National Kidney Foundation guidelines for the management of dyslipidemias in patients with chronic kidney disease. To convert serum creatinine from mg/dL to mmol/L, multiply by 88.4. Abbreviations: Cr, serum creatinine; ESRD, end-stage renal disease; NCEP, National Cholesterol Education Program; CVD, cardiovascular disease; GFR, glomerular filtration rate; CKD, chronic kidney disease; K/DOQI, Kidney Disease Outcomes Quality Initiative. American Journal of Kidney Diseases 2003 41, S11-S21DOI: (10.1016/S0272-6386(03)00119-7)

Fig 2 Ages covered by the current guidelines, and those covered by previous guidelines developed for use in the general population. American Journal of Kidney Diseases 2003 41, S11-S21DOI: (10.1016/S0272-6386(03)00119-7)

Fig 3 The chain of logic for evidence supporting the treatment of low-density lipoprotein cholesterol in patients with chronic kidney disease. See text for details. Abbreviations: LDL, low-density lipoprotein; CHD, coronary heart disease; CKD, chronic kidney disease. American Journal of Kidney Diseases 2003 41, S11-S21DOI: (10.1016/S0272-6386(03)00119-7)

Fig 4 The relative coronary heart disease risk reduction in subgroups of patients from major lipid-lowering trials in the general population. The bars indicate the mean relative risk reduction (compared to a reference level of 0% reduction), with a higher number indicating a proportionally greater reduction in risk. The error bars represent 95% confidence intervals. There were at least 20,000 patients in each category (divided between “no” and “yes”). The only category where the risk reduction was statistically different was for baseline LDL (lower panel), where patients with a higher baseline LDL had a greater reduction in risk, although patients with lower and higher baseline cholesterol had significant risk reductions. Data are from Table II.2–3 of the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (www.nhlbi.nih.gov/guidelines/cholesterol/index.htm). American Journal of Kidney Diseases 2003 41, S11-S21DOI: (10.1016/S0272-6386(03)00119-7)