Pharmacogenetic Directed Dosing Leads to Optimized Voriconazole Levels in Pediatric Patients Receiving Hematopoietic Stem Cell Transplants Ashley Teusink,

Slides:

Advertisements

Similar presentations

Reduced Intensity Conditioning Allogeneic Stem Cell Transplantation for Adults with Relapsed and Refractory Mantle Cell Lymphoma: A Single Center Retrospective.

Advertisements

Trend, Risk Factors and Outcome of Thrombotic Microangiopathy in Pediatric Hematopoietic Stem Cell Transplant Recipients: A Multi-Institutional Review

Peripheral Blood Expansion of CD38 Bright CD8+ Effector Memory T-Cells Predicts Acute Graft Versus Host Disease with a Diagnostic Accuracy of 87% Pooja.

Phase 1 Study of Maraviroc As Acute Graft-Versus-Host Disease Prophylaxis in Pediatrics Pooja Khandelwal, MD, Tsuyoshi Fukuda, PhD, Ashley Teusink, PharmD,

How to Treat MDS without Stem Cell Transplantation

Biology of Blood and Marrow Transplantation

Outcomes of Diffuse Large B-Cell Lymphoma (DLBCL) Patients Progressing after Autologous Hematopoietic Stem Cell Transplant Maria Gil-Cupello, BA, Gunjan.

Reduced-Intensity Conditioning Hematopoietic Cell Transplantation Is an Effective Treatment for Patients with SLAM-Associated Protein Deficiency/X-linked.

Using A3 Methodology to Identify the Root Cause of a Chemotherapy Error in a Hematopoietic Stem Cell Transplant Patient Kathlene DeGregory, PharmD, BCOP,

Infusion of Ex Vivo Expanded Cord Blood Progenitor Cells Is Associated with Reduced Hospital Days and Utilization of Opiate Infusion and Total Parenteral.

Continuous Intravenous Immunoglobulin and Platelet Infusion in Allogeneic Stem Cell Transplant Patients with Allo-Immune Thrombocytopenia Katerina Ancevski,

Richard Gopez Ancheta, MD, Carol Burian, CCRP, William E

Vitamin A Deficiency Is Associated with Increased Risk of Acute Graft Versus Host Disease in Children Dana T. Lounder, MD, Sonata Jodele, MD, Pooja Khandelwal,

Predictive Value of Pre-Transplant PET/CT Scan before Autologous Stem Cell Transplant in Mantle Cell Lymphoma Brian Hess, MD, Kathryn Trinkaus, Ph.D.,

Inhaled Cyclosporine Solution for the Treatment of Bronchiolitis Obliterans Following Hematopoietic Stem Cell Transplantation (HSCT) or Lung Transplantation

Biology of Blood and Marrow Transplantation

Eculizumab Treatment Improves Survival in Patients with High-Risk Hematopoietic Stem Cell Transplant (HSCT)-Associated Thrombotic Microangiopathy (TMA)

Optimizing Data Collection for Long-Term Follow-Up after Hematopoietic Stem Cell Transplant Jaskiran Kaur, Madhu Ragupathi, Alysa Pleiner, Luda Kushner,

Access to Hematopoietic Cell Transplantation in the United States

Gregory Wallace, DO, Sonata Jodele, MD, Kasiani C

Alemtuzumab/Low Dose Radiation Conditioning Regimen in Allogeneic Hematopoietic Stem Cell Transplantation for Adult Patients with Sickle Cell Disease.

A Genetic Modifier of the Gut Microbiome Influences the Risk of Graft-versus-Host Disease and Bacteremia After Hematopoietic Stem Cell Transplantation

Let Them Eat! Comparing a Neutropenic Diet to a Food Safety Based Diet in Patients Undergoing Hematopoietic Stem Cell Transplantation (HSCT) Cynthia.

Early Soluble ST2 Elevation Predicts Future Left Ventricular Systolic Dysfunction after Stem Cell Transplant Christopher E. Dandoy, MD, MSc, Thomas D.

Pulmonary Hypertension Associated with Bronchiolitis Obliterans after Stem Cell Transplant Christopher E. Dandoy, MD, MSc, Abigail Pate, Mikako Warren,

High-Dose Weekly AmBisome Antifungal Prophylaxis in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation: A Pharmacokinetic Study Parinda.

Treatment of Severe Mucositis Pain with Oral Ketamine Mouthwash

Outcomes of Diffuse Large B-Cell Lymphoma (DLBCL) Patients Progressing after Autologous Hematopoietic Stem Cell Transplant Maria Gil-Cupello, BA, Gunjan.

A Process to Facilitate Decision Making in Pediatric Stem Cell Transplantation: The Individualized Care Planning and Coordination Model Justin N. Baker,

Pauline A. Daniels, DO, Stella M

A Single Ultra High Dose of Vitamin D is Safe and Feasible in Early Peri-Transplant Period to Prevent Vitamin D Deficiency in Pediatric HSCT Recipients

Early Use of Inhaled Ribavirin Can Improve Outcomes in High Risk Hematopoietic Stem Cell Transplant and Leukemia Patients with RSV Infection Ron Mihelic,

Genotype-Directed Dosing Leads to Optimized Voriconazole Levels in Pediatric Patients Receiving Hematopoietic Stem Cell Transplantation Ashley Teusink,

Gregory Wallace, Sonata Jodele, Jonathan Howell, Kasiani C

Follicular Lymphoma: Prognostic Factors, Conventional Therapies, and Hematopoietic Cell Transplantation Laurie H. Sehn, Timothy S. Fenske, Ginna G. Laport

Pooja Khandelwal, Rebecca A. Marsh, D. Scott Schmid, Kay W

Alternate-Day Micafungin Antifungal Prophylaxis in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation: A Pharmacokinetic Study Parinda.

Hematopoietic Cell Transplantation for Acute Leukemia and Advanced Myelodysplastic Syndrome in Fanconi Anemia Richard Mitchell, Todd Defor, John E. Wagner,

Increased Vitamin D Binding Protein Levels Are Associated with Improved Overall Survival Following Bone Marrow Transplant in Children Nathan Luebbering,

Graft-Versus-Host Disease Targets Granulosa Cell of Ovarian Follicle and Causes Infertility after Allogeneic Hematopoietic Stem Cell Transplantation

Patient Self-Perceived Burden and Caregiver Burden in Recipients of Hematopoietic Stem Cell Transplantation: A Longitudinal Study Examining Gender Differences

Hemophagocytic Lymphohistiocytosis (HLH) after Hematopoietic Stem Cell Transplant (HSCT) or an Impostor: A Word of Caution! Anant Vatsayan, MD, Linda.

Cytokine Profile of Engraftment Syndrome in Pediatric Hematopoietic Stem Cell Transplant Recipients Pooja Khandelwal, Sabine Mellor-Heineke, Najibah.

A Pharmacokinetic and Pharmacodynamic Study of Maraviroc as Acute Graft-versus- Host Disease Prophylaxis in Pediatric Allogeneic Stem Cell Transplant Recipients.

Results of 10-Year Single Center Experience with Pharmacokinetics Directed Intravenous Busulfan, Cyclophosphamide and Etoposide Preparative Regimen in.

Haploidentical Bmt and Post Transplant Cyclophosphamide: First Peruvian Experience Alfredo Wong, Mariela Moreno, Mayra Castillo, Juan Navarro, Lourdes.

Single Center Experience with High Dose Melphalan and Two Day Washout in Patients with Multiple Myeloma on Hemodialysis Undergoing Autologous Stem Cell.

Histologic Features of Intestinal Thrombotic Microangiopathy in Patients with High Risk TMA after HSCT Javier El-Bietar, MD, Mikako Warren, MD, Christopher.

Sonata Jodele, Kejian Zhang, Christopher E. Dandoy, Kasiani C

Regression Models for Hazard Rates Versus Cumulative Incidence Probabilities in Hematopoietic Cell Transplantation Data Brent R. Logan, Mei-Jie Zhang,

Incidence of Adrenal Insufficiency in Patients with Multiple Myeloma during High Dose Chemotherapy and Autologous Stem Cell Transplant Ahmad Hatem Mattour,

Gerard Socié, K. Scott Baker, Smita Bhatia

What is quality in a transplant program?

Hema Dave, Benjamin Hanisch, Rithu Mukherjee, David A

Impact of Pharmacogenetics and Therapeutic Drug Monitoring On Optimizing Voriconazole Dosing in Pediatric Patients Undergoing Hematopoietic Cell Transplantation

Participation in Clinical Research: Perspectives of Adult Patients and Parents of Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation

Pretransplant Absolute Lymphocyte Counts Impact the Pharmacokinetics of Alemtuzumab Rebecca A. Marsh, Tsuyoshi Fukuda, Chie Emoto, Lisa Neumeier, Pooja.

Does Cryopreserved Hematopoietic Stem Cell Product Need an Expiration Date? Recipients Engrafted Despite Infusion of Products over Five Years in Storage.

Management of Cytokine Release Syndrome (CRS) in Patients Undergoing Chimeric Antigen Receptor Modified (CAR) T-Cell Therapy Following Autologous Stem.

Chimeric Antigen Receptor–Modified T Cells: Clinical Translation in Stem Cell Transplantation and Beyond Stanley R. Riddell, Michael C. Jensen, Carl.

Evaluation of a Data-Derived Algorithm for Preemptive Use of Plerixafor for Stem Cell Harvest in Patients Eligible for Autologous Stem Cell Transplant.

Higher Total Nucleated Cell Dose, but Not CD3+, 4+, 8+, or 34+ Cell Dose, Is Associated with Better Overall and Progression-Free Survival after Allogeneic.

Mammen Chandy Biology of Blood and Marrow Transplantation

IL-8 Levels Early after Bone Marrow Transplant are Associated with Later Complications of Stem Cell Transplantation Nikhil Dole, Nathan Luebbering, Nicholas.

Cardiac Dysfunction after Stem Cell Transplantation: Can Peritransplant Cardiac Troponin-I Predict Future Issues? Seth Joshua Rotz, MD, Thomas D. Ryan,

Monocyte Recovery at Day 100 Is Associated with Improved Survival in Multiple Myeloma Patients Who Undergo Allogeneic Hematopoietic Cell Transplantation

Analysis of 402 Cord Blood Units to Assess Factors Influencing Infused Viable CD34+ Cell Dose: The Critical Determinant of Engraftment Duncan Purtill,

William Berquist, MD Gastrointestinal Endoscopy

Mary Eapen Biology of Blood and Marrow Transplantation

Donald R. Dengel, Aaron S. Kelly, Lei Zhang, Qi Wang, James S

Presentation transcript:

Pharmacogenetic Directed Dosing Leads to Optimized Voriconazole Levels in Pediatric Patients Receiving Hematopoietic Stem Cell Transplants Ashley Teusink, Pharm D, MBA, BCPS, Alexander Vinks, PharmD, PhD, FCP, Kejian Zhang, MD, MBA, Tsuyoshi Fukuda, PhD, Stella M. Davies, MBBS, PhD, Adam Lane, Alexandra Filipovich, MD, Parinda A. Mehta, MD Biology of Blood and Marrow Transplantation Volume 20, Issue 2, Pages S99-S100 (February 2014) DOI: 10.1016/j.bbmt.2013.12.132 Copyright © 2014 Terms and Conditions

Fig 1 Genotype directed initial Voriconazole dosing and subsequent dose adjustment algorithm Biology of Blood and Marrow Transplantation 2014 20, S99-S100DOI: (10.1016/j.bbmt.2013.12.132) Copyright © 2014 Terms and Conditions

Figure 2 Biology of Blood and Marrow Transplantation 2014 20, S99-S100DOI: (10.1016/j.bbmt.2013.12.132) Copyright © 2014 Terms and Conditions