An Endothelial Contribution to Coronary Vessels

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An Endothelial Contribution to Coronary Vessels Gonzalo del Monte, Richard Paul Harvey Cell Volume 151, Issue 5, Pages 932-934 (November 2012) DOI: 10.1016/j.cell.2012.11.004 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Cartoons Showing Possible Modes of Formation of Coronary Endothelium (A) Heart structure at embryonic day (E) 9.5 and E13.5. Boxes indicate regions highlighted in (B–D). (B) Epicardial origin. At E9.5, the proepicardium releases cell clusters or vesicles to the pericardial cavity that attach to the myocardial wall and spread to give rise at E11.5 to the epicardium and epicardial-derived cells (arrows, route 1), which differentiate predominantly into smooth muscle cells of the coronary plexus and cardiac fibroblasts (right). Some existing endothelial cells or angioblasts derived from the liver sinusoids may be swept along with or encapsulated by proepicardial clusters (white arrows and route 2). Some PE cells may be multipotent for endothelial cells, perivascular cells, and fibroblasts (asterisk, route 3). (C) Sinus venosus origin. At E10.5, the sinus venosus endothelium sprouts into and around the subepicardial space of the atrium (arrows) and ventricles (arrowhead) and by E12.5 (box, right) has formed the venous and possibly parts of the arterial coronary endothelial plexus (Red-Horse et al., 2010). (D) Endocardial origin. At E10.5, endocardial cells of the ventricles undergo budding, sprouting, or EMT directly to form at E11.5 (box, right) endothelial cells of the coronary arteries and possibly of some of the veins (Wu et al., 2012). Abbreviations: a, atrium; avc, atrioventricular canal; ca, coronary arteries; cv, coronary veins; EPDCs, epicardial-derived cells; epi, epicardium; f, fibroblasts; lp, liver primordium; lv, left ventricle; oft, outflow tract; pe, proepicardium; rv, right ventricle; SMCs, smooth muscle cells; subepi, subepicardium; sv, sinus venosus; v, ventricle. Cell 2012 151, 932-934DOI: (10.1016/j.cell.2012.11.004) Copyright © 2012 Elsevier Inc. Terms and Conditions