Advanced Biology Burns Skin Cancer

Burns: 1st Degree 2 million treated each year 12,000 die Use rule of nines – see fig 5.8

Burns: 1st Degree Only Epidermis is damaged Usually redness, swelling and pain Heals in 1-2 weeks SUNBURN

Burns: 1st Degree

Burns: 1st Degree One severe sunburn can double your risk of skin cancer.

Sunburn

Burns: 2nd Degree Injure epidermis and upper region of dermis Skin regeneration occurs w/in 3-4 weeks

Burns: 2nd Degree

Burns: 2nd Degree

Burns: 3rd Degree Burns entire thickness of skin

Burns: 3rd Degree

Burns: 3rd Degree

Burns: 3rd Degree

Burns: 3rd Degree

Burns: 3rd Degree

Burns: 3rd Degree

Burns: 3rd Degree

Skin Grafting Rejection by body

Skin Cancer Benign = Non-cancerous Malignant = Cancerous

Basal Cell Carcinoma Least malignant Most common skin cancer Lesions on sun exposed face Slow growing W/ Surgery - 99 % full cure

Squamous Cell Carcinoma Arises from keratinocytes of stratum spinosum Scalp, ears Grow rapidly If detected early – complete cure is likely

Malignant Melanoma Cancer of melanocytes Most dangerous Pigmented moles

ABCD Rule A = Asymmetry B = Border Irregularity C = Color D = Diameter

ABCD Rule A = sides do not match B = not smooth C = several different colors D = Larger than 6 mm

Developmental Aspects Skin is formed Fetus is covered with downy coat of delicate hairs called lanugo coat

Developmental Aspects Vernix caseosa Produced by sebaceous glands, protects fetus skin

Developmental Aspects Rate of epidermal cell replacement slows Skin thins Susceptible to bruises

Developmental Aspects Lubricating substances become deficient – skin dries out Elastic fibers clump and degenerate

Developmental Aspects Collagen fibers become fewer Hypodermal layer decreases Decrease in melanocytes and Langerhans’ cells Hair loss